Enantioselective Dearomatization of Substituted Phenols via Organocatalyzed Electrophilic Amination

doi:10.1021/acs.orglett.3c02100

	Enantioselective Dearomatization of Substituted Phenols via Organocatalyzed Electrophilic Amination
	Ye, Zidan; Liu, Wei; Gu, Huanchao; Yang, Xiaoyu
	2023-07-01
发表期刊	ORGANIC LETTERS (IF:4.9[JCR-2023],4.5[5-Year])
ISSN	1523-7060
EISSN	1523-7052
发表状态	已发表
DOI	10.1021/acs.orglett.3c02100
摘要	Highly efficient and stereoselective dearomatizationof substitutedphenols was achieved via chiral phosphoric acid-catalyzed electrophilic para-amination with commercially available azodicarboxylates.This protocol readily afforded a series of chiral 2,5-cyclohexadienonesbearing 4-aza-quaternary stereocenters with excellent yields and enantioselectivities(& LE;99% yield and >99% ee). Easy scale-up of this reactiontoa gram scale and diverse derivatizations of the chiral products into & alpha;-tertiary amines and & alpha;-tertiary heterocycles derivativeswell demonstrated the potential of this method.
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收录类别	SCI
语种	英语
资助项目	NSFC[
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:001040446500001
出版者	AMER CHEMICAL SOC
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/321449
专题	物质科学与技术学院物质科学与技术学院_PI研究组_杨晓瑜组物质科学与技术学院_硕士生物质科学与技术学院_博士生
通讯作者	Yang, Xiaoyu
作者单位	ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
第一作者单位	物质科学与技术学院
通讯作者单位	物质科学与技术学院
第一作者的第一单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Ye, Zidan,Liu, Wei,Gu, Huanchao,et al. Enantioselective Dearomatization of Substituted Phenols via Organocatalyzed Electrophilic Amination[J]. ORGANIC LETTERS,2023.
APA	Ye, Zidan,Liu, Wei,Gu, Huanchao,&Yang, Xiaoyu.(2023).Enantioselective Dearomatization of Substituted Phenols via Organocatalyzed Electrophilic Amination.ORGANIC LETTERS.
MLA	Ye, Zidan,et al."Enantioselective Dearomatization of Substituted Phenols via Organocatalyzed Electrophilic Amination".ORGANIC LETTERS (2023).