Small-sample learning reveals propionylation in determining global protein homeostasis

doi:10.1038/s41467-023-38414-8

	Small-sample learning reveals propionylation in determining global protein homeostasis
	Shui, Ke 1; Wang, Chenwei 1; Zhang, Xuedi2 ; Ma, Shanshan 1; Li, Qinyu 1; Ning, Wanshan 1; Zhang, Weizhi 1; Chen, Miaomiao 1; Peng, Di 1; Hu, Hui 1; Fang, Zheng 3; Guo, Anyuan 1; Gao, Guanjun2 ; Ye, Mingliang 3; Zhang, Luoying 1,4; Xue, Yu 1,5
	2023-05-17
发表期刊	NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
EISSN	2041-1723
卷号	14 期号:1
发表状态	已发表
DOI	10.1038/s41467-023-38414-8
摘要	["Proteostasis is fundamental for maintaining organismal health. However, the mechanisms underlying its dynamic regulation and how its disruptions lead to diseases are largely unclear. Here, we conduct in-depth propionylomic profiling in Drosophila, and develop a small-sample learning framework to prioritize the propionylation at lysine 17 of H2B (H2BK17pr) to be functionally important. Mutating H2BK17 which eliminates propionylation leads to elevated total protein level in vivo. Further analyses reveal that H2BK17pr modulates the expression of 14.7-16.3% of genes in the proteostasis network, and determines global protein level by regulating the expression of genes involved in the ubiquitin-proteasome system. In addition, H2BK17pr exhibits daily oscillation, mediating the influences of feeding/fasting cycles to drive rhythmic expression of proteasomal genes. Our study not only reveals a role of lysine propionylation in regulating proteostasis, but also implements a generally applicable method which can be extended to other issues with little prior knowledge.","The development of a new smallsample learning framework, KprFunc, leads to the discovery of an important role for lysine propionylation in determining global protein homeostasis, mediated by a critical propionylation site on histone H2B, H2BK17pr."]
URL	查看原文
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of China["31930021","32022035","31970633","32200956"] ; Ministry of Science and Technology of China["2021ZD0203200-02","2022YFC2704300","2021YFF0702000"] ; Hubei Innovation Group Project[2021CFA005] ; China Postdoctoral Science Foundation["2019T120648","2020M682395","2021M701337"]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001001374800026
出版者	NATURE PORTFOLIO
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/321435
专题	生命科学与技术学院生命科学与技术学院_PI研究组_高冠军组
通讯作者	Zhang, Luoying; Xue, Yu
作者单位	1.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Ctr Artificial Intelligence Biol, Key Lab Mol Biophys,Minist Educ, Wuhan 430074, Hubei, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 4.Hubei Prov Key Lab Oral & Maxillofacial Dev & Rege, Wuhan 430022, Hubei, Peoples R China 5.Nanjing Univ, Inst Artificial Intelligence Biomed, Nanjing 210031, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Shui, Ke,Wang, Chenwei,Zhang, Xuedi,et al. Small-sample learning reveals propionylation in determining global protein homeostasis[J]. NATURE COMMUNICATIONS,2023,14(1).
APA	Shui, Ke.,Wang, Chenwei.,Zhang, Xuedi.,Ma, Shanshan.,Li, Qinyu.,...&Xue, Yu.(2023).Small-sample learning reveals propionylation in determining global protein homeostasis.NATURE COMMUNICATIONS,14(1).
MLA	Shui, Ke,et al."Small-sample learning reveals propionylation in determining global protein homeostasis".NATURE COMMUNICATIONS 14.1(2023).