Structural biology of SARS-CoV-2 Mpro and drug discovery

doi:10.1016/j.sbi.2023.102667

KMS > 免疫化学研究所

	Structural biology of SARS-CoV-2 Mpro and drug discovery
	Duan, Yinkai1,2 ; Wang, Haofeng1,2 ; Yuan, Zhenghong 3,4; Yang, Haitao1,2
	2023-08-04
发表期刊	CURRENT OPINION IN STRUCTURAL BIOLOGY (IF:6.1[JCR-2023],6.0[5-Year])
ISSN	0959-440X
EISSN	1879-033X
卷号	82 期号:102667
发表状态	已发表
DOI	10.1016/j.sbi.2023.102667
摘要	Since its outbreak in late 2019, the COVID-19 pandemic has drawn enormous attention worldwide as a consequence of being the most disastrous infectious disease in the past century. As one of the most immediately druggable targets of SARS-CoV-2, the main protease (Mpro) has been studied thoroughly. In this review, we provide a comprehensive summary of recent advances in structural studies of Mpro, which provide new knowledge about Mpro in terms of its biological function, structural characteristics, substrate specificity, and autocleavage process. We examine the remarkable strides made in targeting Mpro for drug discovery during the pandemic. We summarize insights into the current understanding of the structural features of Mpro and the discovery of existing Mprotargeting drugs, illuminating pathways for the future development of anti-SARS-CoV-2 therapeutics.
关键词	SARS-CoV-2 Main protease Structural studies Autocleavage Drug discovery
URL	查看原文
收录类别	SCI
语种	英语
资助项目	Guangzhou Laboratory["SRPG22-003","YDZX20213100001556"] ; Science and Technology Commission of Shanghai Municipality["20XD1422900","ZD2021CY001"] ; Shanghai Municipal Science and Technology Major Project[92169109] ; null[SRPG22-011]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:001053553800001
出版者	CURRENT BIOLOGY LTD
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/317441
专题	免疫化学研究所免疫化学研究所_特聘教授组_饶子和组免疫化学研究所_PI研究组_杨海涛组
通讯作者	Yuan, Zhenghong; Yang, Haitao
作者单位	1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Sch Life Sci & Technol, Shanghai, Peoples R China 2.Shanghai Clin Res & Trial Ctr, Shanghai, Peoples R China 3.Fudan Univ, Shanghai Med Coll, Sch Basic Med Sci, Key Lab Med Mol Virol,MOE,NHC,CAMS, Shanghai, Peoples R China 4.Fudan Univ, Inst Infect Dis & Biosecur, Shanghai Med Coll, Shanghai, Peoples R China
第一作者单位	免疫化学研究所
通讯作者单位	免疫化学研究所
第一作者的第一单位	免疫化学研究所
推荐引用方式 GB/T 7714	Duan, Yinkai,Wang, Haofeng,Yuan, Zhenghong,et al. Structural biology of SARS-CoV-2 Mpro and drug discovery[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY,2023,82(102667).
APA	Duan, Yinkai,Wang, Haofeng,Yuan, Zhenghong,&Yang, Haitao.(2023).Structural biology of SARS-CoV-2 Mpro and drug discovery.CURRENT OPINION IN STRUCTURAL BIOLOGY,82(102667).
MLA	Duan, Yinkai,et al."Structural biology of SARS-CoV-2 Mpro and drug discovery".CURRENT OPINION IN STRUCTURAL BIOLOGY 82.102667(2023).