Enolate-Azide [3+2]-Cycloaddition Reaction Suitable for DNA-Encoded Library Synthesis

doi:10.1021/acs.bioconjchem.3c00235

KMS > 免疫化学研究所

	Enolate-Azide [3+2]-Cycloaddition Reaction Suitable for DNA-Encoded Library Synthesis
	Pan, Kangyin1 ; Yao, Ying1 ; Zhang, Yiyuan1 ; Gu, Yuang1 ; Wang, Yan1 ; Ma, Peixiang 2; Hou, Wei 3; Yang, Guang1 ; Zhang, Shuning1 ; Xu, Hongtao1
	2023-07-01
发表期刊	BIOCONJUGATE CHEMISTRY (IF:4.0[JCR-2023],4.3[5-Year])
ISSN	1043-1802
EISSN	1520-4812
卷号	34 期号:8 页码:1459-1466
发表状态	已发表
DOI	10.1021/acs.bioconjchem.3c00235
摘要	The DNA-encoded chemical library (DEL) is a powerfulhit selectiontechnique in either basic science or innovative drug discovery. Withthe aim to circumvent the issue concerning DNA barcode damage in aconventional on-DNA copper-catalyzed azide-alkyne cycloadditionreaction (CuAAC), we have successfully developed the first DNA-compatibleenolate-azide [3 + 2] cycloaddition reaction. The merits ofthis DEL chemistry include metal-free reaction and high DNA fidelity,high conversions and easy operation, broad substrate scope, and readyaccess to the highly substituted 1,4,5-trisubstituted triazoles. Thus,it will not only further enrich the DEL chemistry toolbox but alsowill have great potential in practical DEL synthesis.
关键词	Copper compounds Cycloaddition Olefins Basic science Chemical libraries Copper catalyzed azide alkyne cycloaddition Cycloaddition reaction Drug discovery Enolates High conversions Metal-free reactions Selection techniques [3+2]-cycloaddition
URL	查看原文
收录类别	SCI ; EI
语种	英语
资助项目	National Natural Science Foundation of China[
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
WOS记录号	WOS:001026587100001
出版者	AMER CHEMICAL SOC
EI入藏号	20233014453470
EI主题词	DNA
EI分类号	461.2 Biological Materials and Tissue Engineering ; 802.2 Chemical Reactions ; 804.1 Organic Compounds
原始文献类型	Journal article (JA)
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/317180
专题	免疫化学研究所免疫化学研究所_特聘教授组_功能筛选实验室免疫化学研究所_特聘教授组_抗体设计学实验室生命科学与技术学院_硕士生生命科学与技术学院_博士生
通讯作者	Zhang, Shuning; Xu, Hongtao
作者单位	1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies SIAIS, Shanghai 201210, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Orthoped, Shanghai 200025, Peoples R China 3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
第一作者单位	免疫化学研究所
通讯作者单位	免疫化学研究所
第一作者的第一单位	免疫化学研究所
推荐引用方式 GB/T 7714	Pan, Kangyin,Yao, Ying,Zhang, Yiyuan,et al. Enolate-Azide [3+2]-Cycloaddition Reaction Suitable for DNA-Encoded Library Synthesis[J]. BIOCONJUGATE CHEMISTRY,2023,34(8):1459-1466.
APA	Pan, Kangyin.,Yao, Ying.,Zhang, Yiyuan.,Gu, Yuang.,Wang, Yan.,...&Xu, Hongtao.(2023).Enolate-Azide [3+2]-Cycloaddition Reaction Suitable for DNA-Encoded Library Synthesis.BIOCONJUGATE CHEMISTRY,34(8),1459-1466.
MLA	Pan, Kangyin,et al."Enolate-Azide [3+2]-Cycloaddition Reaction Suitable for DNA-Encoded Library Synthesis".BIOCONJUGATE CHEMISTRY 34.8(2023):1459-1466.