ShanghaiTech University Knowledge Management System
| The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity | |
| 2023-05-22 | |
| Source Publication | MOLECULES
 |
| EISSN | 1420-3049 |
| Volume | 28Issue:10 |
| Status | 已发表 |
| DOI | 10.3390/molecules28104254 |
| Abstract | Artemisia divaricate belongs to the Artemisia genus of the family of Compositae, a sort of perennial herb endemic in most regions of China. For the first time, a phytochemical investigation was carried out on the whole plant of Artemisia divaricate, resulting in the identification of 39 sesquiterpenes, with 9 of them being new (1-9). The structures of the new compounds were fully established using extensive analysis of MS and 1D and 2D NMR spectroscopic data and density functional theory (DFT) NMR calculations. Their structures involve germacrane, eudesmane, and bisabolane types. All the new isolates were evaluated for their anti-inflammatory activities in lipopolysaccharide (LPS)-stimulated murine macrophages of RAW 264.7 cells. Compounds 2 and 8 showed a significant inhibition effect on NO production, with IC50 values of 5.35 +/- 0.75 and 7.68 +/- 0.54 mu M, respectively. |
| Keyword | Artemisia divaricate sesquiterpene divaricanolide A-I anti-inflammatory activity |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Science and Technology Commission of Shanghai Municipality[20430780300] ; National Natural Science Foundation of China[21920102003] ; Shanghai Pujiang Program[22PJD102] |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| WOS ID | WOS:000996789100001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/316422 |
| Collection | 生命科学与技术学院 生命科学与技术学院_特聘教授组_叶阳组 |
| Corresponding Author | Tang, Chunping; Ye, Yang |
| Affiliation | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China |
| Corresponding Author Affilication | School of Life Science and Technology |
| Recommended Citation GB/T 7714 | Yan, Siqi,Ke, Changqiang,Feng, Zheling,et al. The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity[J]. MOLECULES,2023,28(10). |
| APA | Yan, Siqi,Ke, Changqiang,Feng, Zheling,Tang, Chunping,&Ye, Yang.(2023).The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity.MOLECULES,28(10). |
| MLA | Yan, Siqi,et al."The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity".MOLECULES 28.10(2023). |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
Edit Comment
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.