The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity

doi:10.3390/molecules28104254

	The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity
	Yan, Siqi 1,2,3; Ke, Changqiang 1,2; Feng, Zheling 1,2; Tang, Chunping 1,2; Ye, Yang1,2,3,4
	2023-05-22
发表期刊	MOLECULES
EISSN	1420-3049
卷号	28 期号:10
发表状态	已发表
DOI	10.3390/molecules28104254
摘要	Artemisia divaricate belongs to the Artemisia genus of the family of Compositae, a sort of perennial herb endemic in most regions of China. For the first time, a phytochemical investigation was carried out on the whole plant of Artemisia divaricate, resulting in the identification of 39 sesquiterpenes, with 9 of them being new (1-9). The structures of the new compounds were fully established using extensive analysis of MS and 1D and 2D NMR spectroscopic data and density functional theory (DFT) NMR calculations. Their structures involve germacrane, eudesmane, and bisabolane types. All the new isolates were evaluated for their anti-inflammatory activities in lipopolysaccharide (LPS)-stimulated murine macrophages of RAW 264.7 cells. Compounds 2 and 8 showed a significant inhibition effect on NO production, with IC50 values of 5.35 +/- 0.75 and 7.68 +/- 0.54 mu M, respectively.
关键词	Artemisia divaricate sesquiterpene divaricanolide A-I anti-inflammatory activity
URL	查看原文
收录类别	SCI
语种	英语
资助项目	Science and Technology Commission of Shanghai Municipality[20430780300] ; National Natural Science Foundation of China[21920102003] ; Shanghai Pujiang Program[22PJD102]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000996789100001
出版者	MDPI
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/316422
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_叶阳组
通讯作者	Tang, Chunping; Ye, Yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yan, Siqi,Ke, Changqiang,Feng, Zheling,et al. The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity[J]. MOLECULES,2023,28(10).
APA	Yan, Siqi,Ke, Changqiang,Feng, Zheling,Tang, Chunping,&Ye, Yang.(2023).The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity.MOLECULES,28(10).
MLA	Yan, Siqi,et al."The First Phytochemical Investigation of Artemisia divaricate: Sesquiterpenes and Their Anti-Inflammatory Activity".MOLECULES 28.10(2023).