Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans

doi:10.1016/j.celrep.2023.112598

	Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans
	Peng, Jing-Yi1,2,3 ; Liu, Xuqing1 ; Zeng, Xian-Ting1 ; Hao, Yue1,2,3 ; Zhang, Jia-Hui1,2,3,7 ; Li, Qian 4,5,6; Tong, Xia-Jing1
	2023-06
发表期刊	CELL REPORTS (IF:7.5[JCR-2023],8.5[5-Year])
ISSN	2639-1856
卷号	42 期号:6
发表状态	已发表
DOI	10.1016/j.celrep.2023.112598
摘要	Age-associated neurodegenerative disorders such as Parkinson's and Alzheimer's diseases are mainly caused by protein aggregation. The etiologies of these neurodegenerative diseases share a chemical environment. However, how chemical cues modulate neurodegeneration remains unclear. Here, we found that in Caenorhabditis elegans, exposure to pheromones in the L1 stage accelerates neurodegeneration in adults. Perception of pheromones ascr#3 and ascr#10 is mediated by chemosensory neurons ASK and ASI. ascr#3 perceived by G protein-coupled receptor (GPCR) DAF-38 in ASK activates glutamatergic transmission into AIA interneurons. ascr#10 perceived by GPCR STR-2 in ASI activates the secretion of neuropeptide NLP-1, which binds to the NPR-11 receptor in AIA. Activation of both ASI and ASK is required and sufficient to remodel neurodevelopment via AIA, which triggers insulin-like signaling and inhibits autophagy in adult neurons non-cell-autonomously. Our work reveals how pheromone perception at the early developmental stage modulates neurodegeneration in adults and provides insights into how the external environment impacts neurodegenerative diseases.
收录类别	SCI
语种	英语
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/306469
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_童夏静组免疫化学研究所_PI研究组_赵简组
共同第一作者	Liu, Xuqing
通讯作者	Tong, Xia-Jing
作者单位	1.School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China 2.Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China 3.University of Chinese Academy of Sciences, Beijing 100049, China 4.Songjiang Institute and Songjiang Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China 5.Center for Brain Science, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China 6.Department of Anatomy and Physiology, Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health in Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 7.Lingang Laboratory, Shanghai 200031, China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Peng, Jing-Yi,Liu, Xuqing,Zeng, Xian-Ting,et al. Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans[J]. CELL REPORTS,2023,42(6).
APA	Peng, Jing-Yi.,Liu, Xuqing.,Zeng, Xian-Ting.,Hao, Yue.,Zhang, Jia-Hui.,...&Tong, Xia-Jing.(2023).Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans.CELL REPORTS,42(6).
MLA	Peng, Jing-Yi,et al."Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans".CELL REPORTS 42.6(2023).