Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase
Hou, Lidan1,2; Zhao, Jie3; Gao, Shaobing1,4; Ji, Tong3; Song, Tianyu1,2; Li, Yining1; Wang, Jingjie1; Geng, Chenlu1; Long, Min1; Chen, Jiang3
2019-02
发表期刊SCIENCE ADVANCES
ISSN2375-2548
卷号5期号:2
发表状态已发表
DOI10.1126/sciadv.aau7130
摘要About 257 million people with chronic infection of hepatitis B virus (HBV) worldwide are at high risk of developing terminal liver diseases. Reactivation of virus replication has been frequently reported in those patient populations receiving imatinib (an Abl kinase inhibitor) or bortezomib (a proteasome inhibitor) to treat concurrent diseases, but the underlying mechanism for this reactivation is unknown. We report that the HBV polymerase protein is recruited by Cdt2 to the cullin-RING ligase 4 (CRL4) for ubiquitination and proteasome degradation and that this process is stimulated by the c-Abl nonreceptor tyrosine kinase. Genetic ablation of the Abl-CRL4(cdt2) axis or pharmaceutical inhibition of this process stabilizes HBV polymerase protein and increases viral loads in HBV-infected liver cancer cell lines. Our study reveals a kinase-dependent activation of CRL4 ubiquitin ligase that can be targeted for blocking HBV replication.
收录类别SCI ; SCIE ; EI
语种英语
资助项目National Natural Science Foundation[91429302]
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000460145700034
出版者AMER ASSOC ADVANCEMENT SCIENCE
EI入藏号20190706500651
EI主题词Amino acids ; Cell culture ; Enzymes
EI分类号Biology:461.9 ; Organic Compounds:804.1
WOS关键词MYELOMA DRUG LENALIDOMIDE ; X-PROTEIN ; LEUKEMIA PATIENT ; REACTIVATION ; BINDING ; DESTRUCTION ; INFECTION ; INHIBITORS ; COMPLEX ; DDB1
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/30555
专题生命科学与技术学院_PI研究组_仓勇组
通讯作者Cang, Yong
作者单位1.Zhejiang Univ, Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
3.Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Gen Surg, Hangzhou 310058, Zhejiang, Peoples R China
4.Zhengzhou Univ, Affiliated Canc Hosp, Zhengzhou 450008, Henan, Peoples R China
第一作者单位生命科学与技术学院
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Hou, Lidan,Zhao, Jie,Gao, Shaobing,et al. Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase[J]. SCIENCE ADVANCES,2019,5(2).
APA Hou, Lidan.,Zhao, Jie.,Gao, Shaobing.,Ji, Tong.,Song, Tianyu.,...&Cang, Yong.(2019).Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase.SCIENCE ADVANCES,5(2).
MLA Hou, Lidan,et al."Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase".SCIENCE ADVANCES 5.2(2019).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Hou, Lidan]的文章
[Zhao, Jie]的文章
[Gao, Shaobing]的文章
百度学术
百度学术中相似的文章
[Hou, Lidan]的文章
[Zhao, Jie]的文章
[Gao, Shaobing]的文章
必应学术
必应学术中相似的文章
[Hou, Lidan]的文章
[Zhao, Jie]的文章
[Gao, Shaobing]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。