ShanghaiTech University Knowledge Management System
Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase | |
Hou, Lidan1,2; Zhao, Jie3; Gao, Shaobing1,4; Ji, Tong3; Song, Tianyu1,2; Li, Yining1; Wang, Jingjie1; Geng, Chenlu1; Long, Min1; Chen, Jiang3 | |
2019-02 | |
发表期刊 | SCIENCE ADVANCES |
ISSN | 2375-2548 |
卷号 | 5期号:2 |
发表状态 | 已发表 |
DOI | 10.1126/sciadv.aau7130 |
摘要 | About 257 million people with chronic infection of hepatitis B virus (HBV) worldwide are at high risk of developing terminal liver diseases. Reactivation of virus replication has been frequently reported in those patient populations receiving imatinib (an Abl kinase inhibitor) or bortezomib (a proteasome inhibitor) to treat concurrent diseases, but the underlying mechanism for this reactivation is unknown. We report that the HBV polymerase protein is recruited by Cdt2 to the cullin-RING ligase 4 (CRL4) for ubiquitination and proteasome degradation and that this process is stimulated by the c-Abl nonreceptor tyrosine kinase. Genetic ablation of the Abl-CRL4(cdt2) axis or pharmaceutical inhibition of this process stabilizes HBV polymerase protein and increases viral loads in HBV-infected liver cancer cell lines. Our study reveals a kinase-dependent activation of CRL4 ubiquitin ligase that can be targeted for blocking HBV replication. |
收录类别 | SCI ; SCIE ; EI |
语种 | 英语 |
资助项目 | National Natural Science Foundation[91429302] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000460145700034 |
出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
EI入藏号 | 20190706500651 |
EI主题词 | Amino acids ; Cell culture ; Enzymes |
EI分类号 | Biology:461.9 ; Organic Compounds:804.1 |
WOS关键词 | MYELOMA DRUG LENALIDOMIDE ; X-PROTEIN ; LEUKEMIA PATIENT ; REACTIVATION ; BINDING ; DESTRUCTION ; INFECTION ; INHIBITORS ; COMPLEX ; DDB1 |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/30555 |
专题 | 生命科学与技术学院_PI研究组_仓勇组 |
通讯作者 | Cang, Yong |
作者单位 | 1.Zhejiang Univ, Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Gen Surg, Hangzhou 310058, Zhejiang, Peoples R China 4.Zhengzhou Univ, Affiliated Canc Hosp, Zhengzhou 450008, Henan, Peoples R China |
第一作者单位 | 生命科学与技术学院 |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Hou, Lidan,Zhao, Jie,Gao, Shaobing,et al. Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase[J]. SCIENCE ADVANCES,2019,5(2). |
APA | Hou, Lidan.,Zhao, Jie.,Gao, Shaobing.,Ji, Tong.,Song, Tianyu.,...&Cang, Yong.(2019).Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase.SCIENCE ADVANCES,5(2). |
MLA | Hou, Lidan,et al."Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase".SCIENCE ADVANCES 5.2(2019). |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 |
修改评论
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。