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ShanghaiTech University Knowledge Management System
| Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus | |
| 2019-01-20 | |
| 发表期刊 | JOURNAL OF GENETICS AND GENOMICS (IF:6.6[JCR-2023],5.8[5-Year]) |
| ISSN | 1673-8527 |
| 卷号 | 46期号:1页码:31-40 |
| 发表状态 | 已发表 |
| DOI | 10.1016/j.jgg.2018.11.004 |
| 摘要 | Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy homeostasis. Interestingly, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network. Copyright (C) 2019, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved. |
| 关键词 | BDNF Transsynaptic tracing Obesity Feeding Thermogenesis |
| 收录类别 | SCI ; SCIE ; CSCD |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[31771169] ; National Natural Science Foundation of China[91857104] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS类目 | Biochemistry & Molecular Biology ; Genetics & Heredity |
| WOS记录号 | WOS:000460039200004 |
| 出版者 | SCIENCE PRESS |
| WOS关键词 | NEUROTROPHIC FACTOR ; ZONA INCERTA ; BODY-WEIGHT ; ENERGY-BALANCE ; SEVERE OBESITY ; MESSENGER-RNA ; HYPOTHALAMUS ; LESIONS ; FOOD ; ACTIVATION |
| 原始文献类型 | Article |
| 引用统计 | 正在获取...
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| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/30443 |
| 专题 | 生命科学与技术学院_本科生 生命科学与技术学院_PI研究组_沈伟组 生命科学与技术学院_博士生 |
| 通讯作者 | Shen, Wei L.; Yang, Jiajun |
| 作者单位 | 1.ShanghaiTech Univ, Undergrad Program, Shanghai 201210, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Shanghai Jiao Tong Univ, Dept Neurol, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China 6.Shanghai Univ Med & Hlth Sci, Shanghai Peoples Hosp East 6, Dept Neurol, Shanghai 201306, Peoples R China |
| 第一作者单位 | 上海科技大学; 生命科学与技术学院 |
| 通讯作者单位 | 上海科技大学; 生命科学与技术学院 |
| 第一作者的第一单位 | 上海科技大学 |
| 推荐引用方式 GB/T 7714 | Luo, Fang,Mu, Yuling,Gao, Cuicui,et al. Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus[J]. JOURNAL OF GENETICS AND GENOMICS,2019,46(1):31-40. |
| APA | Luo, Fang.,Mu, Yuling.,Gao, Cuicui.,Xiao, Yan.,Zhou, Qian.,...&Yang, Jiajun.(2019).Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus.JOURNAL OF GENETICS AND GENOMICS,46(1),31-40. |
| MLA | Luo, Fang,et al."Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus".JOURNAL OF GENETICS AND GENOMICS 46.1(2019):31-40. |
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