Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

doi:10.1007/s00018-018-2940-7

	Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression
	Pu, Mengfan1,2 ; Chen, Jing 1; Tao, Zhouteng 1; Miao, Lingling 1; Qi, Xinming 1; Wang, Yizheng 3; Ren, Jin1
	2019-02
发表期刊	CELLULAR AND MOLECULAR LIFE SCIENCES (IF:6.2[JCR-2023],7.7[5-Year])
ISSN	1420-682X
卷号	76 期号:3 页码:441-451
发表状态	已发表
DOI	10.1007/s00018-018-2940-7
摘要	MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a majority of biological processes via regulating target gene expression. The post-transcriptional repression through miRNA seed region binding to 3 UTR of target mRNA is considered as the canonical mode of miRNA-mediated gene regulation. However, emerging evidence suggests that other regulatory modes exist beyond the canonical mechanism. In particular, the function of intranuclear miRNA in gene transcriptional regulation is gradually revealed, with evidence showing their contribution to gene silencing or activating. Therefore, miRNA-mediated regulation of gene transcription not only expands our understanding of the molecular mechanism underlying miRNA regulatory function, but also provides new evidence to explain its ability in the sophisticated regulation of many bioprocesses. In this review, mechanisms of miRNA-mediated gene transcriptional and post-transcriptional regulation are summarized, and the synergistic effects among these actions which form a regulatory network of a miRNA on its target are particularly elaborated. With these discussions, we aim to emphasize the importance of miRNA regulatory network on target gene regulation and further highlight the potential application of the network mode in the achievement of a more effective and stable modulation of the target gene expression.
关键词	miRNA target recognition miRNA non-seed sequence function miRNA cellular distribution miRNA-related nucleic acid drugs
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000456932000003
出版者	SPRINGER BASEL AG
WOS关键词	MESSENGER-RNAS ; ANTISENSE TRANSCRIPTS ; DUAL INHIBITION ; NUCLEAR EXPORT ; UP-REGULATION ; MICRORNAS ; COMPLEMENTARY ; CLEAVAGE ; TRANSLATION ; RECOGNITION
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/30228
专题	生命科学与技术学院_硕士生生命科学与技术学院_特聘教授组_任进组
通讯作者	Ren, Jin
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Ctr Drug Safety Evaluat & Res, 501 Haike Rd, Shanghai 201203, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China 3.Beijing Inst Basic Med Sci, Brain Sci Ctr, 27 Taiping Rd, Beijing 100850, Peoples R China
第一作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Pu, Mengfan,Chen, Jing,Tao, Zhouteng,et al. Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2019,76(3):441-451.
APA	Pu, Mengfan.,Chen, Jing.,Tao, Zhouteng.,Miao, Lingling.,Qi, Xinming.,...&Ren, Jin.(2019).Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression.CELLULAR AND MOLECULAR LIFE SCIENCES,76(3),441-451.
MLA	Pu, Mengfan,et al."Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression".CELLULAR AND MOLECULAR LIFE SCIENCES 76.3(2019):441-451.