Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression
Pu, Mengfan1,2; Chen, Jing1; Tao, Zhouteng1; Miao, Lingling1; Qi, Xinming1; Wang, Yizheng3; Ren, Jin1
2019-02
发表期刊CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN1420-682X
卷号76期号:3页码:441-451
发表状态已发表
DOI10.1007/s00018-018-2940-7
摘要MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a majority of biological processes via regulating target gene expression. The post-transcriptional repression through miRNA seed region binding to 3 UTR of target mRNA is considered as the canonical mode of miRNA-mediated gene regulation. However, emerging evidence suggests that other regulatory modes exist beyond the canonical mechanism. In particular, the function of intranuclear miRNA in gene transcriptional regulation is gradually revealed, with evidence showing their contribution to gene silencing or activating. Therefore, miRNA-mediated regulation of gene transcription not only expands our understanding of the molecular mechanism underlying miRNA regulatory function, but also provides new evidence to explain its ability in the sophisticated regulation of many bioprocesses. In this review, mechanisms of miRNA-mediated gene transcriptional and post-transcriptional regulation are summarized, and the synergistic effects among these actions which form a regulatory network of a miRNA on its target are particularly elaborated. With these discussions, we aim to emphasize the importance of miRNA regulatory network on target gene regulation and further highlight the potential application of the network mode in the achievement of a more effective and stable modulation of the target gene expression.
关键词miRNA target recognition miRNA non-seed sequence function miRNA cellular distribution miRNA-related nucleic acid drugs
收录类别SCI ; SCIE
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
WOS类目Biochemistry & Molecular Biology ; Cell Biology
WOS记录号WOS:000456932000003
出版者SPRINGER BASEL AG
WOS关键词MESSENGER-RNAS ; ANTISENSE TRANSCRIPTS ; DUAL INHIBITION ; NUCLEAR EXPORT ; UP-REGULATION ; MICRORNAS ; COMPLEMENTARY ; CLEAVAGE ; TRANSLATION ; RECOGNITION
原始文献类型Review
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/30228
专题生命科学与技术学院_硕士生
生命科学与技术学院_特聘教授组_任进组
通讯作者Ren, Jin
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Ctr Drug Safety Evaluat & Res, 501 Haike Rd, Shanghai 201203, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
3.Beijing Inst Basic Med Sci, Brain Sci Ctr, 27 Taiping Rd, Beijing 100850, Peoples R China
第一作者单位生命科学与技术学院
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Pu, Mengfan,Chen, Jing,Tao, Zhouteng,et al. Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2019,76(3):441-451.
APA Pu, Mengfan.,Chen, Jing.,Tao, Zhouteng.,Miao, Lingling.,Qi, Xinming.,...&Ren, Jin.(2019).Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression.CELLULAR AND MOLECULAR LIFE SCIENCES,76(3),441-451.
MLA Pu, Mengfan,et al."Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression".CELLULAR AND MOLECULAR LIFE SCIENCES 76.3(2019):441-451.
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