An online resource for GPCR structure determination and analysis

doi:10.1038/s41592-018-0302-x

KMS > iHuman研究所

	An online resource for GPCR structure determination and analysis
	Munk, Christian 1; Mutt, Eshita 2; Isberg, Vignir 1,7; Nikolajsen, Louise F.1; Bibbe, Janne M.1; Flock, Tilman 2; Hanson, Michael A.3; Stevens, Raymond C.4,5,6 ; Deupi, Xavier 2; Gloriam, David E.1
	2019-02
发表期刊	NATURE METHODS (IF:36.1[JCR-2023],45.6[5-Year])
ISSN	1548-7091
卷号	16 期号:2 页码:151-162
发表状态	已发表
DOI	10.1038/s41592-018-0302-x
摘要	G-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into appropriate cellular responses and mediate the actions of one-third of drugs. GPCR structural studies have revealed the general bases of receptor activation, signaling, drug action and allosteric modulation, but so far cover only 13% of nonolfactory receptors. We broadly surveyed the receptor modifications/engineering and methods used to produce all available GPCR crystal and cryo-electron microscopy (cryo-EM) structures, and present an interactive resource integrated in GPCRdb (http://www.gpcrdb.org) to assist users in designing constructs and browsing appropriate experimental conditions for structure studies.
收录类别	SCI ; SCIE
语种	英语
资助项目	COST Action[CM1207]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemical Research Methods
WOS记录号	WOS:000457193400009
出版者	NATURE PUBLISHING GROUP
WOS关键词	PROTEIN-COUPLED RECEPTOR ; CRYO-EM STRUCTURE ; CRYSTAL-STRUCTURE ; GLP-1 RECEPTOR ; INFORMATION-SYSTEM ; DRUG DESIGN ; STABILIZATION ; MUTAGENESIS ; ACTIVATION ; RHODOPSIN
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/30224
专题	iHuman研究所 iHuman研究所_特聘教授组_Raymond Stevens组
通讯作者	Munk, Christian; Gloriam, David E.
作者单位	1.Univ Copenhagen, Dept Drug Design & Pharmacol, Copenhagen, Denmark 2.Paul Scherrer Inst, Villigen, Switzerland 3.GPCR Consortium, San Marcos, CA USA 4.Univ Southern Calif, USC Michelson Ctr Convergent Biosci, Bridge Inst, Dept Biol Sci, Los Angeles, CA USA 5.Univ Southern Calif, USC Michelson Ctr Convergent Biosci, Bridge Inst, Dept Chem, Los Angeles, CA USA 6.ShanghaiTech Univ, iHuman Inst, Shanghai, Peoples R China 7.Novozymes AS, Copenhagen, Denmark
推荐引用方式 GB/T 7714	Munk, Christian,Mutt, Eshita,Isberg, Vignir,et al. An online resource for GPCR structure determination and analysis[J]. NATURE METHODS,2019,16(2):151-162.
APA	Munk, Christian.,Mutt, Eshita.,Isberg, Vignir.,Nikolajsen, Louise F..,Bibbe, Janne M..,...&Gloriam, David E..(2019).An online resource for GPCR structure determination and analysis.NATURE METHODS,16(2),151-162.
MLA	Munk, Christian,et al."An online resource for GPCR structure determination and analysis".NATURE METHODS 16.2(2019):151-162.