"Guide Star" Assisted Noninvasive Photoacoustic Measurement of Glucose

doi:10.1021/acssensors.8b00905

	"Guide Star" Assisted Noninvasive Photoacoustic Measurement of Glucose
	Zhang, Ruochong 1; Gao, Fei1,2 ; Feng, Xiaohua 1; Jin, Haoran 1; Zhang, Shaohua 1; Liu, Siyu 1; Luo, Yunqi 1; Xing, Bengang 3; Zheng, Yuanjin 1
	2018-12
发表期刊	ACS SENSORS (IF:8.2[JCR-2023],8.4[5-Year])
ISSN	2379-3694
卷号	3 期号:12 页码:2550-2557
发表状态	已发表
DOI	10.1021/acssensors.8b00905
摘要	A novel "guide star" assisted photoacoustic (GSPA) method for noninvasive glucose measurement has been proposed. Instead of receiving PA signals that are directly generated by tissue, a virtual photodiode is employed to amplify the PA signal difference regarding amplitude and peak arrival time caused by glucose concentration variations in an indirect way. Being different from traditional PA spectroscopy, this method can improve sensitivity and accuracy by optimizing optical path lengths (or tissue thickness). On the other hand, being superior to near-infrared (NIR) spectroscopy, it utilizes both optical absorption and acoustic propagation velocity information confered by PA signals. Theoretical analysis and simulation have been done to illustrate how the concentration change affects the PA waveform. In vitro experiments on aqueous glucose solution were conducted with concentrations varying in human physiological range (50-350 mg/dL). Performance of quartz cuvettes with 1 mm and 2 mm optical path lengths were compared in terms of correlation quality (R-2), degree of agreement (Bland-Altman plot), and clinical accuracy (Clarke's Error Grid analysis) to demonstrate the scalability of sensitivity provided by the indirect method. Longer optical length shows better sensitivity and accuracy in this case. Moreover, detection was also done on human blood serum to further prove the potential of the proposed method for clinical application. Our proposed method provides a solution to enhance sensitivity, facilitating development of portable and low-cost PA sensors with low power laser diodes for noninvasive glucose monitoring and other applications.
关键词	noninvasive glucose monitoring photoacoustics near-infrared virtual photodiode Diabetes Mellitus
收录类别	SCI ; SCIE ; EI
语种	英语
WOS研究方向	Chemistry ; Science & Technology - Other Topics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Analytical ; Nanoscience & Nanotechnology
WOS记录号	WOS:000454962400011
出版者	AMER CHEMICAL SOC
WOS关键词	2-DIMENSION ; MICROSCOPY
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/29596
专题	信息科学与技术学院_PI研究组_高飞组
通讯作者	Zheng, Yuanjin
作者单位	1.Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore 2.ShanghaiTech Univ, Sch Informat Sci & Technol, Shanghai 201210, Peoples R China 3.Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore
推荐引用方式 GB/T 7714	Zhang, Ruochong,Gao, Fei,Feng, Xiaohua,et al. "Guide Star" Assisted Noninvasive Photoacoustic Measurement of Glucose[J]. ACS SENSORS,2018,3(12):2550-2557.
APA	Zhang, Ruochong.,Gao, Fei.,Feng, Xiaohua.,Jin, Haoran.,Zhang, Shaohua.,...&Zheng, Yuanjin.(2018)."Guide Star" Assisted Noninvasive Photoacoustic Measurement of Glucose.ACS SENSORS,3(12),2550-2557.
MLA	Zhang, Ruochong,et al.""Guide Star" Assisted Noninvasive Photoacoustic Measurement of Glucose".ACS SENSORS 3.12(2018):2550-2557.