上海科技大学知识管理系统

本技术一般涉及预防或治疗与突变体CX26，CX32和//或CX30半通道相关的疾病的组合物和方法。 本技术还涉及施用有效量的抗CX26半通道抗体以治疗患有或倾向于患有外胚层发育不良2，Clouston型(OMIM No.129500)，角膜炎-鱼鳞病-耳聋综合征(Kids； OMIM No.148210)，和//或X型夏科-马利-牙神经病(CMTXL)； OMIM No.302800)。

The present technology relates generally to compositions and methods of preventing or treating diseases associated with mutant Cx26, Cx32, and//or Cx30hemichannels. The present technology also relates to administering the anti-Cx26 hemichannel antibodies in effective amounts to treat a subject suffering from, or predisposed to, ectodermal dysplasia 2, Clouston type (OMIM No. 129500), Keratitis-ichthyosis-deafness syndrome (KIDS; OMIM No. 148210), and //or type X Charcot-Marie-Tooth neuropathy (CMTXl; OMIM No. 302800).