上海科技大学知识管理系统

本发明提供了特异性结合酸敏感离子通道1A(ASIC1A)蛋白的免疫球蛋白相关组合物(例如抗体或其抗原结合片段)及其用途。 还提供了施用有效量的抗-ASIC1A抗体以治疗患有酸中毒或易患酸中毒的受试者，或治疗患有由ASIC1A活性和//或信号改变引起的或与ASIC1A活性和//或信号改变相关的疾病的受试者的方法，所述疾病包括缺血性中风和相关病症。

Provided are immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that specifically bind acid-sensing ion channel 1a (ASIC1a) protein and uses of the same. Also provided is a method of administering an effective amount of the anti-ASIC1a antibodies to treat a subject suffering from, or predisposed to, acidosis, or to treat a subject suffering from a disease caused by or related to altered ASIC1a activity and//or signaling, including ischemic stroke and related conditions.