Solid-State Structure of Abeta (A beta) in Alzheimer's Disease

doi:10.2174/0929866524666170208155108

	Solid-State Structure of Abeta (A beta) in Alzheimer's Disease
	Lu, Jun-Xia; Dong, Xing-Qi; Zhang, Jian-Jun
	2017
发表期刊	PROTEIN AND PEPTIDE LETTERS
ISSN	0929-8665
卷号	24 期号:4 页码:322-330
发表状态	已发表
DOI	10.2174/0929866524666170208155108
摘要	Alzheimer's disease (AD) has become the most common neurodegenerative disease. The deposition of amyloid fibrils in the brain is one of the characteristics of AD. The fibrils are composed of amyloid-beta peptide (A beta). A beta is produced through a series event of protease cleavage of a transmembrane protein called beta-amyloid precursor protein (APP) which is commonly expressed in the brain. The production of A beta and its propensity to aggregation to form oligomers and fibrils are believed to initiate a sequence of events that lead to AD dementia. The production of A beta is influenced by the transmembrane domain (TM) structure of APP. The structure variety of different A beta assemblies including oligomers and fibrils may result in different neurotoxicity to the brain. Therefore, enormous work has been carried out to study the structure of APP TM and various A beta assemblies. Solid-state NMR has advantages in studying immobile protein structures with large molecular weight. In this review, solid-state NMR structure of APP TM and different A beta assemblies will be discussed, especially various A beta amyloid fibril structures. This structural information greatly enhanced our understanding in AD, providing fundamental knowledge that will help in finding a treatment for AD.
关键词	Alzheimer's disease amyloid precursor protein amyloid-beta peptide amyloid fibrils oligomers solid-state NMR
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000401271400006
出版者	BENTHAM SCIENCE PUBL LTD
WOS关键词	AMYLOID PRECURSOR PROTEIN ; NUCLEAR-MAGNETIC-RESONANCE ; ATOMIC-RESOLUTION STRUCTURE ; TRANSMEMBRANE DOMAIN ; FIBRIL STRUCTURE ; SHEET STRUCTURE ; ELECTRON-MICROSCOPY ; MOLECULAR-STRUCTURE ; GAMMA-SECRETASE ; IN-REGISTER
原始文献类型	Review
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2939
专题	生命科学与技术学院生命科学与技术学院_PI研究组_陆珺霞组生命科学与技术学院_硕士生生命科学与技术学院_博士生
通讯作者	Lu, Jun-Xia
作者单位	ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Lu, Jun-Xia,Dong, Xing-Qi,Zhang, Jian-Jun. Solid-State Structure of Abeta (A beta) in Alzheimer's Disease[J]. PROTEIN AND PEPTIDE LETTERS,2017,24(4):322-330.
APA	Lu, Jun-Xia,Dong, Xing-Qi,&Zhang, Jian-Jun.(2017).Solid-State Structure of Abeta (A beta) in Alzheimer's Disease.PROTEIN AND PEPTIDE LETTERS,24(4),322-330.
MLA	Lu, Jun-Xia,et al."Solid-State Structure of Abeta (A beta) in Alzheimer's Disease".PROTEIN AND PEPTIDE LETTERS 24.4(2017):322-330.