Cytotoxic sesquiterpene lactones from Artemisia anomala

doi:10.1016/j.phytol.2017.04.038

	Cytotoxic sesquiterpene lactones from Artemisia anomala
	Li, Lu 1,2; Liu, Hongchun 3; Tang, Chunping 2; Yao, Sheng 2; Ke, Changqiang 2; Xu, Chenghui 3; Ye, Yang2,4
	2017-06
发表期刊	PHYTOCHEMISTRY LETTERS (IF:1.3[JCR-2023],1.4[5-Year])
ISSN	1874-3900
卷号	20 页码:177-180
发表状态	已发表
DOI	10.1016/j.phytol.2017.04.038
摘要	Two new sesquiterpene lactones, 8 alpha-acetoxy-1,10 alpha-epoxy-2-oxo-guaia-3,11(13)-dien-12,6 alpha-olide (1) and 13-acetoxy- 1-oxo-4 alpha-hydroxy-eudesman-2(11)-dien-12,6 alpha-olide (2), along with six known analogs (3-8), were isolated from the whole plant of Artemisia anomala S. Moore. Their structures were elucidated by extensive analysis of spectroscopic data. Compounds 6 and 7 exhibited in vitro moderate cytotoxicity against A549 cells with IC50 values of 0.6 and 0.9 mu M, and HepG2 cells with IC50 values of 5.4 and 3.0 mu M, respectively.
关键词	Artemisia anomala Compositae Sesquiterpene lactones Structure elucidation Cytotoxicity
收录类别	SCI
语种	英语
资助项目	Chinese Academy of Sciences[GJHZ1678] ; Chinese Academy of Sciences[GJHZ1739]
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
WOS类目	Plant Sciences ; Chemistry, Medicinal
WOS记录号	WOS:000405467600035
出版者	ELSEVIER SCIENCE BV
WOS关键词	FARNESYL-PROTEIN TRANSFERASE ; NF-KAPPA-B ; DIMERIC GUAIANOLIDES ; INHIBITORS ; ARTEMINOLIDE ; SYLVATICA
原始文献类型	Article
通讯作者	Ye, Yang
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2916
专题	生命科学与技术学院_特聘教授组_叶阳组
通讯作者	Ye, Yang
作者单位	1.Nanchang Univ, Coll Pharm, Nanchang 330006, Jiangxi, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Lu,Liu, Hongchun,Tang, Chunping,et al. Cytotoxic sesquiterpene lactones from Artemisia anomala[J]. PHYTOCHEMISTRY LETTERS,2017,20:177-180.
APA	Li, Lu.,Liu, Hongchun.,Tang, Chunping.,Yao, Sheng.,Ke, Changqiang.,...&Ye, Yang.(2017).Cytotoxic sesquiterpene lactones from Artemisia anomala.PHYTOCHEMISTRY LETTERS,20,177-180.
MLA	Li, Lu,et al."Cytotoxic sesquiterpene lactones from Artemisia anomala".PHYTOCHEMISTRY LETTERS 20(2017):177-180.