A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex

doi:10.1016/j.neuron.2017.05.022

	A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex
	Li, Min-Yin 1,2,3; Miao, Wan-Ying 1,2; Wu, Qiu-Zi 1,2; He, Shun-Ji 1,2; Yan, Guoquan 4; Yang, Yanrui 5,6; Liu, Jia-Jia 3,5,6; Taketo, M. Mark 7; Yu, Xiang1,2,3,8
	2017-06-21
发表期刊	NEURON (IF:14.7[JCR-2023],16.9[5-Year])
ISSN	0896-6273
卷号	94 期号:6 页码:1155-+
发表状态	已发表
DOI	10.1016/j.neuron.2017.05.022
摘要	The formation of functional synapses requires coordinated assembly of presynaptic transmitter release machinery and postsynaptic trafficking of functional receptors and scaffolds. Here, we demonstrate a critical role of presynaptic cadherin/catenin cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex. Importantly, presynaptic expression of stabilized beta-catenin in either layer (L) 4 excitatory neurons or L2/3 pyramidal neurons significantly upregulated excitatory synaptic transmission and dendritic spine density in L2/3 pyramidal neurons, while its sparse postsynaptic expression in L2/3 neurons had no such effects. In addition, presynaptic b-catenin expression enhanced release probability of glutamatergic synapses. Newly identified beta-catenin-interacting protein p140Cap is required in the presynaptic locus for mediating these effects. Together, our results demonstrate that cadherin/catenin complexes stabilize functional synapses and spines through anterograde signaling in the neocortex and provide important molecular evidence for a driving role of presynaptic components in spinogenesis in the neocortex.
收录类别	SCI
语种	英语
资助项目	Program of Shanghai Subject Chief Scientist[16XD1404800]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000403820200014
出版者	CELL PRESS
WOS关键词	BETA-CATENIN GENE ; DENDRITIC SPINES ; N-CADHERIN ; SYNAPTIC PLASTICITY ; BARREL CORTEX ; PYRAMIDAL CELLS ; MORPHOGENESIS ; SYNAPTOGENESIS ; MATURATION ; BRAIN
原始文献类型	Article
通讯作者	Yu, Xiang
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2910
专题	生命科学与技术学院_特聘教授组_于翔组
通讯作者	Yu, Xiang
作者单位	1.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Neurosci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, State Key Lab Neurosci, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China 5.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China 6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100101, Peoples R China 7.Kyoto Univ, Grad Sch Med, Div Expt Therapeut, Sakyo Ku, Yoshida Konoe Cho, Kyoto 6068501, Japan 8.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Min-Yin,Miao, Wan-Ying,Wu, Qiu-Zi,et al. A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex[J]. NEURON,2017,94(6):1155-+.
APA	Li, Min-Yin.,Miao, Wan-Ying.,Wu, Qiu-Zi.,He, Shun-Ji.,Yan, Guoquan.,...&Yu, Xiang.(2017).A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.NEURON,94(6),1155-+.
MLA	Li, Min-Yin,et al."A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex".NEURON 94.6(2017):1155-+.