Electrospun nanofiber regulates assembly of keratin and vimentin intermediate filaments of PANC-1 pancreatic carcinoma cells
Wang, Yiqun1,2; Lu, Yi1; Gong, Jinkang1; Yao, Yuan1
2019-03
发表期刊MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
卷号96页码:616-624
发表状态已发表
DOI10.1016/j.msec.2018.11.072
摘要Intermediate filaments, together with actin microfilaments and microtubules constituent the cytoskeleton of mammalian cells, involving in various cellular activities. The roles of intermediate filaments in cell skeleton reorganization when responding with extracellular matrix (ECM) nanostructure are poorly understood yet. To unveil the effects of fibrous composition and orientation on cells, we developed electrospun nanofibers of varying topology and components, and the effects on assembly of intermediate filaments as keratin and vimentin were investigated in detail. We found that aligned nanofibers enhanced expression of E-cadherin and promoted assembly of keratin intermediate filaments. Meanwhile, the compositional variation show different preference on up-regulation of the two intermediate filaments. Compared to keratin, the assembly of vimentin intermediate filaments were promoted by incorporating bovine serum albumin (BSA) functionalized graphene oxide (BSA-GO) into polycaprolactone (PCL) nanofibers. Thus, our findings elucidate how the different physical factors of fibrous extracellular matrix affect the reorganization of cytoskeleton by assembly of keratin and vimentin intermediate filaments.
关键词Electrospun nanofibers Intermediate filaments Aligned nanofibers Keratin Vimentin
收录类别EI ; SCIE ; SCI
语种英语
WOS研究方向Materials Science
WOS类目Materials Science, Biomaterials
WOS记录号WOS:000456760700064
出版者ELSEVIER SCIENCE BV
EI入藏号20184906211055
EI主题词Body fluids ; Cells ; Cytology ; Graphene ; Keratin ; Mammals
EI分类号Biological Materials and Tissue Engineering:461.2 ; Nanotechnology:761 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Solid State Physics:933
WOS关键词MODIFIED GRAPHENE OXIDE ; OSTEOGENIC DIFFERENTIATION ; CANCER-CELLS ; STEM-CELLS ; IN-VITRO ; MIGRATION ; INVASION ; ADHESION ; TUMOR ; DELIVERY
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/29097
专题物质科学与技术学院_硕士生
物质科学与技术学院_PI研究组_龚晋慷组
附属学校、幼儿园筹建部
通讯作者Gong, Jinkang; Yao, Yuan
作者单位1.Shanghai Tech Univ, Sch Phys Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
第一作者单位物质科学与技术学院
通讯作者单位物质科学与技术学院
第一作者的第一单位物质科学与技术学院
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Wang, Yiqun,Lu, Yi,Gong, Jinkang,et al. Electrospun nanofiber regulates assembly of keratin and vimentin intermediate filaments of PANC-1 pancreatic carcinoma cells[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2019,96:616-624.
APA Wang, Yiqun,Lu, Yi,Gong, Jinkang,&Yao, Yuan.(2019).Electrospun nanofiber regulates assembly of keratin and vimentin intermediate filaments of PANC-1 pancreatic carcinoma cells.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,96,616-624.
MLA Wang, Yiqun,et al."Electrospun nanofiber regulates assembly of keratin and vimentin intermediate filaments of PANC-1 pancreatic carcinoma cells".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 96(2019):616-624.
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