Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine

doi:10.1038/s41392-023-01345-3

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	Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine
	Qiu, Shaofu 1; Chen, Zhao 2; Zhu, Airu 2; Zeng, Qiuhui 2; Liu, Hongbo 1; Liu, Xiaoqing 2; Ye, Feng 2; Jin, Yingkang 3; Wu, Jie 4; Yang, Chaojie 1; Wang, Qi 1; Chen, Fangli 2; Chen, Lan 2; Tian, Sai 1; Du, Xinying 1; Hu, Qingtao 2; Cheng, Jinling 2; Chen, Canjie 2; Li, Fang 2; Sun, Jing 2; Wang, Yanqun 2; Zhao, Jingxian 2,5; Zhao, Jincun2,5,6,7,8,9 ; Song, Hongbin 1
	2023-03-15
发表期刊	SIGNAL TRANSDUCTION AND TARGETED THERAPY (IF:40.8[JCR-2023],40.5[5-Year])
ISSN	2095-9907
EISSN	2059-3635
卷号	8 期号:1
发表状态	已发表
DOI	10.1038/s41392-023-01345-3
摘要	Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days. PA cases displayed low levels of inflammatory and interferon response, weak antibody response, diminished circulating follicular helper T cells (cTfh), and inadequate specific CD4(+) and CD8(+) T-cell responses during infection, which is distinct from symptomatic infections and resembling impaired immune activation. Administration of a single dose of Ad5-nCoV vaccine to 10 of these PA cases elicited rapid and robust antibody responses as well as coordinated B-cell and cTfh responses, resulting in successful viral clearance. Vaccine-induced antibodies were able to neutralize various variants of concern and persisted for over 6 months, indicating long-term protection. Therefore, our study provides an insight into the immune status of PA infections and highlights vaccination as a potential treatment for prolonged SARS-CoV-2 infections.
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收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China["2021YFC2301102","82172240"] ; National Natural Science Foundation of China["82101836","81901623","82201933","BX2021087"] ; China National Postdoctoral Program for Innovative Talents[2021M690787] ; China Postdoctoral Science Foundation["2022M710892","2021B1515130005"] ; Guangdong Basic and Applied Basic Research Foundation["2022B1515020059","B2022233"] ; Guangdong Medical Technology Research Foundation[202102010143] ; Guangzhou Science and Technology Planning Program Municipal School/Institute-Joint Funded Program[SKLRD-Z-202330] ; State Key Laboratory of Respiratory Diseases[ZNSA-202001] ; Zhong Nanshan Medical Foundation of Guangdong Province["ZNSXS-2020012","ZNSA-2020013","ZNSXS-20220015"] ; null[2021YFC2302004]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000953114100003
出版者	SPRINGERNATURE
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/289992
专题	免疫化学研究所免疫化学研究所_特聘教授组_赵金存组
通讯作者	Zhao, Jingxian; Zhao, Jincun; Song, Hongbin
作者单位	1.Chinese PLA Ctr Dis Control & Prevent, Beijing 100071, Peoples R China 2.Guangzhou Med Univ, Guangzhou Inst Resp Hlth, Natl Clin Res Ctr Resp Dis, State Key Lab Resp Dis,Affiliated Hosp 1, Guangzhou 510182, Guangdong, Peoples R China 3.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Pediat Pulm Dept, Guangzhou 510623, Guangdong, Peoples R China 4.Guangdong Prov Ctr Dis Control & Prevent, Guangzhou 510399, Guangdong, Peoples R China 5.Guangzhou Lab, Guangzhou 510320, Guangdong, Peoples R China 6.Guangzhou Med Univ, Inst Infect Dis, Guangzhou Peoples Hosp 8, Guangzhou 510060, Guangdong, Peoples R China 7.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 8.Shenzhen Third Peoples Hosp, Natl Clin Res Ctr Infect Dis, Shenzhen 518112, Guangdong, Peoples R China 9.Southern Univ Sci & Technol, Affiliated Hosp 2, Sch Med, Shenzhen 518112, Guangdong, Peoples R China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Qiu, Shaofu,Chen, Zhao,Zhu, Airu,et al. Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2023,8(1).
APA	Qiu, Shaofu.,Chen, Zhao.,Zhu, Airu.,Zeng, Qiuhui.,Liu, Hongbo.,...&Song, Hongbin.(2023).Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine.SIGNAL TRANSDUCTION AND TARGETED THERAPY,8(1).
MLA	Qiu, Shaofu,et al."Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine".SIGNAL TRANSDUCTION AND TARGETED THERAPY 8.1(2023).