Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection

doi:10.1016/j.molcel.2017.05.023

	Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection
	Li, Xiang 1,2; Liu, Chu-Xiao 1,2; Xue, Wei 3; Zhang, Yang 1,2; Jiang, Shan 1,2; Yin, Qing-Fei 1,2; Wei, Jia 3; Yao, Run-Wen 1,2; Yang, Li3,4 ; Chen, Ling-Ling1,2,4
	2017-07-20
发表期刊	MOLECULAR CELL (IF:14.5[JCR-2023],16.6[5-Year])
ISSN	1097-2765
卷号	67 期号:2 页码:214-+
发表状态	已发表
DOI	10.1016/j.molcel.2017.05.023
摘要	Circular RNAs (circRNAs) generated via back-splicing are enhanced by flanking complementary sequences. Expression levels of circRNAs vary under different conditions, suggesting participation of protein factors in their biogenesis. Using genome-wide siRNA screening that targets all human unique genes and an efficient circRNA expression reporter, we identify double-stranded RNA-binding domain containing immune factors NF90/NF110 as key regulators in circRNA biogenesis. NF90/NF110 promote circRNA production in the nucleus by associating with intronic RNA pairs juxtaposing the circRNA-forming exon(s); they also interact with mature circRNAs in the cytoplasm. Upon viral infection, circRNA expression is decreased, in part owing to the nuclear export of NF90/NF110 to the cytoplasm. Meanwhile, NF90/NF110 released from circRNP complexes bind to viral mRNAs as part of their functions in antiviral immune response. Our results therefore implicate a coordinated regulation of circRNA biogenesis and function by NF90/NF110 in viral infection.
收录类别	SCI
语种	英语
资助项目	NSFC[91440202] ; NSFC[91540115]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000405908100007
出版者	CELL PRESS
WOS关键词	RNA-PROTEIN INTERACTIONS ; MESSENGER-RNA ; CIRCULAR RNAS ; NONCODING RNAS ; BINDING ; NF90 ; PHOSPHORYLATION ; MECHANISM ; TRANSLATION ; REVEALS
原始文献类型	Article
通讯作者	Yang, Li ; Chen, Ling-Ling
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2891
专题	生命科学与技术学院_特聘教授组_杨力组生命科学与技术学院_特聘教授组_陈玲玲组
通讯作者	Yang, Li; Chen, Ling-Ling
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, State Key Lab Mol Biol, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, 320 Yueyang Rd, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Key Lab Mol Androl, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, 320 Yueyang Rd, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Chinese Acad Sci, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci,Key Lab Computat Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Li, Xiang,Liu, Chu-Xiao,Xue, Wei,et al. Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection[J]. MOLECULAR CELL,2017,67(2):214-+.
APA	Li, Xiang.,Liu, Chu-Xiao.,Xue, Wei.,Zhang, Yang.,Jiang, Shan.,...&Chen, Ling-Ling.(2017).Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection.MOLECULAR CELL,67(2),214-+.
MLA	Li, Xiang,et al."Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection".MOLECULAR CELL 67.2(2017):214-+.