CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo

doi:10.2147/CMAR.S183696

	CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo
	Meng, Wei 1; Wang, Jiajia 1; Wang, Baocheng 1; Liu, Fang 2; Li, Meng 2; Zhao, Yang 1; Zhang, Chenran 1; Li, Qifeng 1; Chen, Juxiang 3; Zhang, Liye4 ; Tang, Yujie 1,2; Ma, Jie 1
	2018
发表期刊	CANCER MANAGEMENT AND RESEARCH (IF:2.5[JCR-2023],2.8[5-Year])
ISSN	1179-1322
卷号	10 页码:5747-5758
发表状态	已发表
DOI	10.2147/CMAR.S183696
摘要	Background: Glioblastoma multiforme (GBM) remains to be one of the top lethal cancer types for adult to date. Current GBM therapies suffer greatly from the highly heterogeneous and adaptable nature of GBM cells, indicating an urgent need of alternative therapeutic options. In this study, we focused on identifying novel epigenetic targeted strategy against GBM.
关键词	THZ1 CDK7 GBM epigenetic targeted therapy transcriptional addiction
收录类别	SCI ; SCIE
语种	英语
资助项目	National Natural Science Foundation of China[81572761] ; National Natural Science Foundation of China[81772655] ; National Natural Science Foundation of China[81500601] ; National Natural Science Foundation of China[81572501] ; National Natural Science Foundation of China[81702453]
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000450393800002
出版者	DOVE MEDICAL PRESS LTD
WOS关键词	STEM-CELLS ; RNA-SEQ ; TRANSCRIPTIONAL DEPENDENCIES ; GLIOBLASTOMA ; CANCER ; MUTATION ; TUMORS ; BRAIN
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/28713
专题	生命科学与技术学院_PI研究组_张力烨组
通讯作者	Tang, Yujie; Ma, Jie
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Pediat Neurosurg, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Dept Pathophysiol, Key Lab Cell Differentiat & Apoptosis,Natl Minist, 280 South Chongqing Rd, Shanghai 200025, Peoples R China 3.Second Mil Med Univ, Changzheng Hosp, Dept Neurosurg, Shanghai, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Zhangs Lab, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Meng, Wei,Wang, Jiajia,Wang, Baocheng,et al. CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo[J]. CANCER MANAGEMENT AND RESEARCH,2018,10:5747-5758.
APA	Meng, Wei.,Wang, Jiajia.,Wang, Baocheng.,Liu, Fang.,Li, Meng.,...&Ma, Jie.(2018).CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo.CANCER MANAGEMENT AND RESEARCH,10,5747-5758.
MLA	Meng, Wei,et al."CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo".CANCER MANAGEMENT AND RESEARCH 10(2018):5747-5758.