Fluoro-Hydroxylation of gem-Difluoroalkenes: Synthesis of O-18-labeled alpha-CF3 Alcohols

doi:10.1002/cjoc.201800426

	Fluoro-Hydroxylation of gem-Difluoroalkenes: Synthesis of O-18-labeled alpha-CF3 Alcohols
	Hu, Jingyu 1; Yang, Yide2 ; Lou, Zhengzhao2 ; Ni, Chuanfa 1; Hu, Jinbo1,2
	2018-12
发表期刊	CHINESE JOURNAL OF CHEMISTRY (IF:5.5[JCR-2023],5.2[5-Year])
ISSN	1001-604X
卷号	36 期号:12 页码:1202-1208
发表状态	已发表
DOI	10.1002/cjoc.201800426
摘要	In this paper, a fluoro-hydroxylation of gem-difluoroalkenes is demonstrated. This protocol uses sequential electrophilic fluorination with Selectfluor and nucleophilic hydroxylation with (H2O)-O-18, which can be used to prepare O-18-labeled alpha-CF3 alcohols from gem-difluorostyrenes. The reaction is typically carried out at room temperature within 4 h in good to excellent yields. Other nucleophiles (besides (H2O)-O-18), such as alcohols, carboxylic acid, acetonitrile and N,N-dimethylformamide, are also suitable for this difunctionalization of gem-difluoroalkenes.
关键词	gem-difluoroalkene difunctionalization electrophilic fluorination O-18-labeling trifluoromethyl carbinol
收录类别	SCI ; SCIE ; IC ; CCR
语种	英语
资助项目	Shanghai Science and Technology program[16QA1404600]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000450017200018
出版者	WILEY-V C H VERLAG GMBH
WOS关键词	CRAFTS-TYPE CYCLIZATION ; QUATERNARY AMMONIUM PHENOXIDES ; CROSS-COUPLING REACTION ; CARBONYL-COMPOUNDS ; STEREOSELECTIVE-SYNTHESIS ; MEDICINAL CHEMISTRY ; GRIGNARD-REAGENTS ; AMINO-ACIDS ; ENANTIOSELECTIVE TRIFLUOROMETHYLATION ; ASYMMETRIC TRIFLUOROMETHYLATION
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/28701
专题	物质科学与技术学院_硕士生物质科学与技术学院_特聘教授组_胡金波组
通讯作者	Hu, Jinbo
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Key Lab Organofluorine Chem, Ctr Excellence Mol Synth,Shanghai Inst Organ Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China 2.ShanghaiTech Univ, Sch Phys Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
通讯作者单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Hu, Jingyu,Yang, Yide,Lou, Zhengzhao,et al. Fluoro-Hydroxylation of gem-Difluoroalkenes: Synthesis of O-18-labeled alpha-CF3 Alcohols[J]. CHINESE JOURNAL OF CHEMISTRY,2018,36(12):1202-1208.
APA	Hu, Jingyu,Yang, Yide,Lou, Zhengzhao,Ni, Chuanfa,&Hu, Jinbo.(2018).Fluoro-Hydroxylation of gem-Difluoroalkenes: Synthesis of O-18-labeled alpha-CF3 Alcohols.CHINESE JOURNAL OF CHEMISTRY,36(12),1202-1208.
MLA	Hu, Jingyu,et al."Fluoro-Hydroxylation of gem-Difluoroalkenes: Synthesis of O-18-labeled alpha-CF3 Alcohols".CHINESE JOURNAL OF CHEMISTRY 36.12(2018):1202-1208.