Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1

doi:10.1038/s41467-018-07291-x

	Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1
	Chiu, Hui 1,2,4,5; Zou, Yan1,6 ; Suzuki, Nobuko 1; Hsieh, Yi-Wen 1; Chuang, Chiou-Fen 1; Wu, Yi-Chun 2,3; Chang, Chieh 1
	2018-11-19
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	9
发表状态	已发表
DOI	10.1038/s41467-018-07291-x
摘要	Two important biological events happen coincidently soon after nerve injury in the peripheral nervous system in C. elegans: removal of axon debris and initiation of axon regeneration. But, it is not known how these two events are co-regulated. Mutants of ced-1, a homolog of Draper and MEGF10, display defects in both events. One model is that those events could be related. But our data suggest that they are actually separable. CED-1 functions in the muscle-type engulfing cells in both events and is enriched in muscle protrusions in close contact with axon debris and regenerating axons. Its two functions occur through distinct biochemical mechanisms; extracellular domain-mediated adhesion for regeneration and extracellular domain binding-induced intracellular domain signaling for debris removal. These studies identify CED-1 in engulfing cells as a receptor in debris removal but as an adhesion molecule in neuronal regeneration, and have important implications for understanding neural circuit repair after injury.
收录类别	SCI ; SCIE
语种	英语
资助项目	National Institutes of Health[5R01GM111320] ; National Institutes of Health[5R01GM098026]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000450405100002
出版者	NATURE PUBLISHING GROUP
WOS关键词	APOPTOTIC CELLS ; C-ELEGANS ; CAENORHABDITIS-ELEGANS ; AXON REGENERATION ; CORPSE ENGULFMENT ; WALLERIAN DEGENERATION ; SCAVENGER RECEPTOR ; NERVOUS-SYSTEM ; NONPROFESSIONAL PHAGOCYTES ; CRKII/DOCK180/RAC PATHWAY
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/28699
专题	生命科学与技术学院_PI研究组_邹燕组
通讯作者	Chang, Chieh
作者单位	1.Univ Illinois, Dept Biol Sci, Chicago, IL 60607 USA 2.Natl Taiwan Univ, Inst Mol & Cellular Biol, Taipei 10617, Taiwan 3.Acad Sinica, Inst Atom & Mol Sci, Taipei 10617, Taiwan 4.CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA 5.CALTECH, HHMI, Pasadena, CA 91125 USA 6.ShanghaiTech Univ, Sch Life Sci, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Chiu, Hui,Zou, Yan,Suzuki, Nobuko,et al. Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1[J]. NATURE COMMUNICATIONS,2018,9.
APA	Chiu, Hui.,Zou, Yan.,Suzuki, Nobuko.,Hsieh, Yi-Wen.,Chuang, Chiou-Fen.,...&Chang, Chieh.(2018).Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1.NATURE COMMUNICATIONS,9.
MLA	Chiu, Hui,et al."Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1".NATURE COMMUNICATIONS 9(2018).