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| Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1 | |
| 2018-11-19 | |
| Source Publication | NATURE COMMUNICATIONS
 |
| ISSN | 2041-1723 |
| Volume | 9 |
| Status | 已发表 |
| DOI | 10.1038/s41467-018-07291-x |
| Abstract | Two important biological events happen coincidently soon after nerve injury in the peripheral nervous system in C. elegans: removal of axon debris and initiation of axon regeneration. But, it is not known how these two events are co-regulated. Mutants of ced-1, a homolog of Draper and MEGF10, display defects in both events. One model is that those events could be related. But our data suggest that they are actually separable. CED-1 functions in the muscle-type engulfing cells in both events and is enriched in muscle protrusions in close contact with axon debris and regenerating axons. Its two functions occur through distinct biochemical mechanisms; extracellular domain-mediated adhesion for regeneration and extracellular domain binding-induced intracellular domain signaling for debris removal. These studies identify CED-1 in engulfing cells as a receptor in debris removal but as an adhesion molecule in neuronal regeneration, and have important implications for understanding neural circuit repair after injury. |
| Indexed By | SCI ; SCIE |
| Language | 英语 |
| Funding Project | National Institutes of Health[5R01GM111320] ; National Institutes of Health[5R01GM098026] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000450405100002 |
| Publisher | NATURE PUBLISHING GROUP |
| WOS Keyword | APOPTOTIC CELLS ; C-ELEGANS ; CAENORHABDITIS-ELEGANS ; AXON REGENERATION ; CORPSE ENGULFMENT ; WALLERIAN DEGENERATION ; SCAVENGER RECEPTOR ; NERVOUS-SYSTEM ; NONPROFESSIONAL PHAGOCYTES ; CRKII/DOCK180/RAC PATHWAY |
| Original Document Type | Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/28699 |
| Collection | 生命科学与技术学院_PI研究组_邹燕组 |
| Corresponding Author | Chang, Chieh |
| Affiliation | 1.Univ Illinois, Dept Biol Sci, Chicago, IL 60607 USA 2.Natl Taiwan Univ, Inst Mol & Cellular Biol, Taipei 10617, Taiwan 3.Acad Sinica, Inst Atom & Mol Sci, Taipei 10617, Taiwan 4.CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA 5.CALTECH, HHMI, Pasadena, CA 91125 USA 6.ShanghaiTech Univ, Sch Life Sci, Shanghai 200031, Peoples R China |
| Recommended Citation GB/T 7714 | Chiu, Hui,Zou, Yan,Suzuki, Nobuko,et al. Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1[J]. NATURE COMMUNICATIONS,2018,9. |
| APA | Chiu, Hui.,Zou, Yan.,Suzuki, Nobuko.,Hsieh, Yi-Wen.,Chuang, Chiou-Fen.,...&Chang, Chieh.(2018).Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1.NATURE COMMUNICATIONS,9. |
| MLA | Chiu, Hui,et al."Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1".NATURE COMMUNICATIONS 9(2018). |
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