Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice

doi:10.1016/j.neuron.2022.11.008

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	Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice
	Zhou, Qian1,2,3 ; Fu, Xin1,2,3 ; Xu, Jianhui 4; Dong, Shiming 3,5; Liu, Changhao1 ; Cheng, Dali 6; Gao, Cuicui1,2,3 ; Huang, Minhua 7; Liu, Zhiduo 3,8; Ni, Xinyan1 ; Hua, Rong 9; Tu, Hongqing1 ; Sun, Hongbin1 ; Shen, Qiwei 9; Chen, Baoting1,2,3 ; Zhang, Jin 10; Zhang, Liye1 ; Yang, Haitao1 ; Hu, Ji1 ; Yang, Wei 7; Pei, Weihua 8; Yao, Qiyuan 9; Sheng, Xing 6; Zhang, Jie 4; Yang, Wen Z.1; Shen, Wei L.1
	2023-02-01
发表期刊	NEURON; (IF:14.7[JCR-2023],16.9[5-Year])
ISSN	0896-6273
EISSN	1097-4199
卷号	111 期号:3 页码:387-404.e8
发表状态	已发表
DOI	10.1016/j.neuron.2022.11.008
摘要	Precise monitoring of internal temperature is vital for thermal homeostasis in mammals. For decades, warm-sensitive neurons (WSNs) within the preoptic area (POA) were thought to sense internal warmth, using this information as feedback to regulate body temperature (Tcore). However, the cellular and molecular mechanisms by which WSNs measure temperature remain largely undefined. Via a pilot genetic screen, we found that silencing the TRPC4 channel in mice substantially attenuated hypothermia induced by light-mediated heating of the POA. Loss-of-function studies of TRPC4 confirmed its role in warm sensing in GABAergic WSNs, causing additional defects in basal temperature setting, warm defense, and fever responses. Furthermore, TRPC4 antagonists and agonists bidirectionally regulated Tcore. Thus, our data indicate that TRPC4 is essential for sensing internal warmth and that TRPC4-expressing GABAergic WSNs function as a novel cellular sensor for preventing Tcore from exceeding set-point temperatures. TRPC4 may represent a potential therapeutic target for managing Tcore.
关键词	internal sensor preoptic area thermoregulation TRPC4 warm-sensitive neurons
学科门类	Neuroscience (all)
URL	查看原文
收录类别	SCOPUS
语种	英语
原始文献类型	Article
Scopus 记录号	2-s2.0-85147212152
来源库	SCOPUS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/286462
专题	免疫化学研究所生命科学与技术学院_PI研究组_张力烨组生命科学与技术学院_PI研究组_胡霁组生命科学与技术学院_PI研究组_沈伟组生命科学与技术学院_硕士生生命科学与技术学院_博士生免疫化学研究所_PI研究组_杨海涛组
共同第一作者	Fu, Xin; Xu, Jianhui
通讯作者	Shen, Wei L.
作者单位	1.School of Life Science and Technology,Shanghai Clinical Research and Trial Center,Shanghai Institute for Advanced Immunochemical Studies,ShanghaiTech University,Shanghai,201210,China; 2.Institute of Neuroscience,State Key Laboratory of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,200031,China; 3.University of Chinese Academy of Sciences,Beijing,100049,China; 4.Thermoregulation and Inflammation Laboratory,Chengdu Medical College,Sichuan,Chengdu,610500,China; 5.Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences (CAS),Shanghai,200031,China; 6.Department of Electronic Engineering,Tsinghua University,Beijing,100084,China; 7.Department of Biophysics,NHC and CAMS Key Laboratory of Medical Neurobiology,Zhejiang University School of Medicine,Hangzhou,310058,China; 8.State Key Laboratory of Integrated Optoelectronics,Institute of Semiconductors,Chinese Academy of Sciences,Beijing,100083,China; 9.Department of General Surgery,Huashan Hospital,Fudan University,Shanghai,200433,China; 10.School of Basic Medical Sciences,Nanchang University,Nanchang,330031,China
第一作者单位	免疫化学研究所
通讯作者单位	免疫化学研究所
第一作者的第一单位	免疫化学研究所
推荐引用方式 GB/T 7714	Zhou, Qian,Fu, Xin,Xu, Jianhui,et al. Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice[J]. NEURON;,2023,111(3):387-404.e8.
APA	Zhou, Qian.,Fu, Xin.,Xu, Jianhui.,Dong, Shiming.,Liu, Changhao.,...&Shen, Wei L..(2023).Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice.NEURON;,111(3),387-404.e8.
MLA	Zhou, Qian,et al."Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice".NEURON; 111.3(2023):387-404.e8.