Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions

doi:10.1038/s41467-023-36042-w

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	Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions
	de Arce, Karen Perez 1,6; Ribic, Adema 1,7; Chowdhury, Dhrubajyoti 2; Watters, Katherine 1,2; Thompson, Garth J. J.3,8 ; Sanganahalli, Basavaraju G. G.3; Lippard, Elizabeth T. C.3,9; Rohlmann, Astrid 4; Strittmatter, Stephen M. M.2,5; Missler, Markus 4; Hyder, Fahmeed 3; Biederer, Thomas 1,2
	2023-12-01
发表期刊	NATURE COMMUNICATIONS;
ISSN	2041-1723
EISSN	2041-1723
卷号	14 期号:1
发表状态	已发表
DOI	10.1038/s41467-023-36042-w
摘要	Multiple trans-synaptic complexes organize synapse development, yet their roles in the mature brain and cooperation remain unclear. We analyzed the postsynaptic adhesion protein LRRTM1 in the prefrontal cortex (PFC), a region relevant to cognition and disorders. LRRTM1 knockout (KO) mice had fewer synapses, and we asked whether other synapse organizers counteract further loss. This determined that the immunoglobulin family member SynCAM 1 controls synapse number in PFC and was upregulated upon LRRTM1 loss. Combined LRRTM1 and SynCAM 1 deletion substantially lowered dendritic spine number in PFC, but not hippocampus, more than the sum of single KO impairments. Their cooperation extended presynaptically, and puncta of Neurexins, LRRTM1 partners, were less abundant in double KO (DKO) PFC. Electrophysiology and fMRI demonstrated aberrant neuronal activity in DKO mice. Further, DKO mice were impaired in social interactions and cognitive tasks. Our results reveal concerted roles of LRRTM1 and SynCAM 1 across synaptic, network, and behavioral domains.
学科门类	Chemistry (all) ; Biochemistry, Genetics and Molecular Biology (all) ; Multidisciplinary ; Physics and Astronomy (all)
URL	查看原文
收录类别	SCOPUS ; SCI
语种	英语
资助项目	Deutsche Forschungsgemeinschaft["SFB1348","TP A03"] ; NIH["R35 NS097283","P30 NS052519","R01 DA018928","R01 MH119826"]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000955886200005
出版者	NATURE PORTFOLIO
原始文献类型	Article
Scopus 记录号	2-s2.0-85146965722
来源库	SCOPUS
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/286453
专题	iHuman研究所 iHuman研究所_PI研究组_Garth John Thompson组
通讯作者	Biederer, Thomas
作者单位	1.Tufts Univ, Dept Neurosci, Sch Med, Boston, MA 02155 USA 2.Yale Sch Med, Dept Neurol, New Haven, CT 06510 USA 3.Yale Sch Med, Dept Radiol & Biomed Imaging, New Haven, CT USA 4.Westfal Wilhelms Univ, Inst Anat & Mol Neurobiol, Munster, Germany 5.Yale Sch Med, Dept Neurosci, New Haven, CT USA 6.Novartis Inst Biomed Res, Neurosci Dept, Cambridge, MA USA 7.Univ Virginia, Dept Psychol, Charlottesville, VA USA 8.ShanghaiTech Univ, iHuman Inst, Shanghai, Peoples R China 9.Univ Texas Austin, Dept Psychiat, Austin, TX USA
推荐引用方式 GB/T 7714	de Arce, Karen Perez,Ribic, Adema,Chowdhury, Dhrubajyoti,et al. Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions[J]. NATURE COMMUNICATIONS;,2023,14(1).
APA	de Arce, Karen Perez.,Ribic, Adema.,Chowdhury, Dhrubajyoti.,Watters, Katherine.,Thompson, Garth J. J..,...&Biederer, Thomas.(2023).Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.NATURE COMMUNICATIONS;,14(1).
MLA	de Arce, Karen Perez,et al."Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions".NATURE COMMUNICATIONS; 14.1(2023).