The swan genome and transcriptome, it is not all black and white

doi:10.1186/s13059-022-02838-0

KMS > 免疫化学研究所

	The swan genome and transcriptome, it is not all black and white
	Karawita, Anjana C.1,2; Cheng, Yuanyuan 3; Chew, Keng Yih 1; Challagulla, Arjun 2; Kraus, Robert 4,5; Mueller, Ralf C.4,5; Tong, Marcus Z. W.1; Hulme, Katina D.1; Bielefeldt-Ohmann, Helle 1; Steele, Lauren E.1; Wu, Melanie 1; Sng, Julian 1; Noye, Ellesandra 1; Bruxner, Timothy J.6; Au, Gough G.2; Lowther, Suzanne 2; Blommaert, Julie 7,8; Suh, Alexander 7,9; McCauley, Alexander J.2; Kaur, Parwinder 10; Dudchenko, Olga 11,12; Aiden, Erez10,11,12,13,14 ; Fedrigo, Olivier 15; Formenti, Giulio 15; Mountcastle, Jacquelyn 15; Chow, William 16; Martin, Fergal J.17; Ogeh, Denye N.17; Thiaud-Nissen, Francoise 18; Howe, Kerstin 16; Tracey, Alan 16; Smith, Jacqueline 19; Kuo, Richard I.19; Renfree, Marilyn B.20; Kimura, Takashi 21; Sakoda, Yoshihiro 21; McDougall, Mathew 22; Spencer, Hamish G.23; Pyne, Michael 24; Tolf, Conny 25; Waldenstroem, Jonas 25; Jarvis, Erich D.15; Baker, Michelle L.2; Burt, David W.1; Short, Kirsty R.1
	2023-01-23
发表期刊	GENOME BIOLOGY (IF:10.1[JCR-2023],16.5[5-Year])
ISSN	1474-760X
卷号	24 期号:1
发表状态	已发表
DOI	10.1186/s13059-022-02838-0
摘要	BackgroundThe Australian black swan (Cygnus atratus) is an iconic species with contrasting plumage to that of the closely related northern hemisphere white swans. The relative geographic isolation of the black swan may have resulted in a limited immune repertoire and increased susceptibility to infectious diseases, notably infectious diseases from which Australia has been largely shielded. Unlike mallard ducks and the mute swan (Cygnus olor), the black swan is extremely sensitive to highly pathogenic avian influenza. Understanding this susceptibility has been impaired by the absence of any available swan genome and transcriptome information.ResultsHere, we generate the first chromosome-length black and mute swan genomes annotated with transcriptome data, all using long-read based pipelines generated for vertebrate species. We use these genomes and transcriptomes to show that unlike other wild waterfowl, black swans lack an expanded immune gene repertoire, lack a key viral pattern-recognition receptor in endothelial cells and mount a poorly controlled inflammatory response to highly pathogenic avian influenza. We also implicate genetic differences in SLC45A2 gene in the iconic plumage of the black swan.ConclusionTogether, these data suggest that the immune system of the black swan is such that should any avian viral infection become established in its native habitat, the black swan would be in a significant peril.
关键词	Genomes Virology Black swan
URL	查看原文
收录类别	SCI
语种	英语
资助项目	Australian Research Council DECRA[DE180100512] ; Wellcome Trust[
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:000924247500001
出版者	BMC
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/282124
专题	免疫化学研究所免疫化学研究所_特聘教授组_结构生物化学实验室
通讯作者	Short, Kirsty R.
作者单位	1.Univ Queensland, Sch Chem & Mol Biosci, St Lucia 4072, Qld, Australia 2.Commonwealth Sci & Ind Res Org, Australian Ctr Dis Preparedness, 5 Portarlington Rd, Geelong 3220, Vic, Australia 3.Univ Sydney, Sch Life & Environm Sci, Sydney 2006, NSW, Australia 4.Max Planck Inst Anim Behav, Dept Migrat, ,, D-78315 Radolfzell am Bodensee, Germany 5.Univ Konstanz, Dept Biol, D-78457 Constance, Germany 6.Univ Queensland, Inst Mol Biosci, St Lucia 4072, Qld, Australia 7.Uppsala Univ, Evolutionary Biol Ctr, Dept Organismal Biol Systemat Biol, Sci Life Lab, S-75236 Uppsala, Sweden 8.New Zealand Inst Plant & Food Res Ltd, Nelson 7010, New Zealand 9.Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich NR4 7TU, Norfolk, England 10.Univ Western Australia, Sch Agr & Environm, Perth, WA 6009, Australia 11.Baylor Coll Med, Ctr Genome Architecture, Dept Mol & Human Genet, Houston, TX 77030 USA 12.Rice Univ, Ctr Theoret Biol Phys, Dept Comp Sci, Houston, TX 77030 USA 13.Broad Inst & Harvard, Cambridge, MA 02139 USA 14.ShanghaiTech, Shanghai Inst Adv Immunochem Studies, ,, Pudong 201210, Peoples R China 15.Rockefeller Univ, Vertebrate Genome Lab, New York, NY 10065 USA 16.Welcome Sanger Inst, Tree Life, Cambridge CB10 1SA, England 17.European Bioinformat Inst, European Mol Biol Lab, Wellcome Genome Campus, Cambridge CB10 1SD, England 18.NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD USA 19.Univ Edinburgh, Roslin Inst, Royal Dick Sch Vet Studies, Easter Bush Campus, Roslin EH25 9RG, Midlothian, Scotland 20.Univ Melbourne, Sch Biosci, Melbourne, Vic 3052, Australia 21.Hokkaido Univ, Fac Vet Med, Sapporo, Hokkaido 0600818, Japan 22.New Zealand Fish & Game Eastern Reg, Rotorua 3046, New Zealand 23.Univ Otago, Dept Zool, Dunedin 9054, New Zealand 24.Currumbin Wildlife Sanctuary, Currumbin, Qld 4223, Australia 25.Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst EEMiS, SE-39182 Kalmar, Sweden
推荐引用方式 GB/T 7714	Karawita, Anjana C.,Cheng, Yuanyuan,Chew, Keng Yih,et al. The swan genome and transcriptome, it is not all black and white[J]. GENOME BIOLOGY,2023,24(1).
APA	Karawita, Anjana C..,Cheng, Yuanyuan.,Chew, Keng Yih.,Challagulla, Arjun.,Kraus, Robert.,...&Short, Kirsty R..(2023).The swan genome and transcriptome, it is not all black and white.GENOME BIOLOGY,24(1).
MLA	Karawita, Anjana C.,et al."The swan genome and transcriptome, it is not all black and white".GENOME BIOLOGY 24.1(2023).