An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

doi:10.3389/fendo.2022.1065263

	An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications
	Liu, Xiaomeng 1,2; Zhang, Zhi 1,3; Song, Yajie 1; Xie, Hengchang4 ; Dong, Meng 2,3
	2023-01-11
发表期刊	FRONTIERS IN ENDOCRINOLOGY (IF:3.9[JCR-2023],4.9[5-Year])
ISSN	1664-2392
卷号	13
发表状态	已发表
DOI	10.3389/fendo.2022.1065263
摘要	Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1. Over the last decade, an in-creasing number of studies have found that activating brown adipose tissue and browning of white adipose tissue can protect against obesity and obesity-related metabolic disease. Brown adipose tissue has gradually become an appealing therapeutic target for the prevention and re-versal of obesity. However, some important issues remain unresolved. It is not certain whether increasing brown adipose tissue activity is the cause or effect of body weight loss or what the risks might be for sympathetic nervous system-dependent non-shivering thermogenesis. In this review, we comprehensively summarize approaches to activating brown adipose tissue and/or browning white adipose tissue, such as cold exposure, exercise, and small-molecule treatment. We highlight the functional mechanisms of small-molecule treatment and brown adipose tissue transplantation using batokine, sympathetic nervous system and/or gut microbiome. Finally, we discuss the causality between body weight loss induced by bariatric surgery, exercise, and brown adipose tissue activity.
关键词	obesity brown adipose tissue (BAT) thermogenesis uncoupling protein1 (UCP1) browning
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收录类别	SCI ; SCOPUS
语种	英语
资助项目	Starting Research Fund from the Xin Xiang Medical University[XYBSKYZZ202135] ; Science and technology innovation talent Program of Henan Province[19HASTIT015]
WOS研究方向	Endocrinology & Metabolism
WOS类目	Endocrinology & Metabolism
WOS记录号	WOS:000917794900001
出版者	FRONTIERS MEDIA SA
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/278855
专题	生命科学与技术学院_博士生
通讯作者	Xie, Hengchang; Dong, Meng
作者单位	1.Zhoukou Normal Univ, Inst Translat Med, Coll Life Sci & Agron, Zhoukou, Henan, Peoples R China 2.Xinxiang Med Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Xinxiang, Henan, Peoples R China 3.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Liu, Xiaomeng,Zhang, Zhi,Song, Yajie,et al. An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications[J]. FRONTIERS IN ENDOCRINOLOGY,2023,13.
APA	Liu, Xiaomeng,Zhang, Zhi,Song, Yajie,Xie, Hengchang,&Dong, Meng.(2023).An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications.FRONTIERS IN ENDOCRINOLOGY,13.
MLA	Liu, Xiaomeng,et al."An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications".FRONTIERS IN ENDOCRINOLOGY 13(2023).