Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells

doi:10.1038/s41467-018-06282-2

	Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells
	Chen, Xufeng 1; Zhao, Jingyao 1; Gu, Chan 2; Cui, Yu 1; Dai, Yuling 1; Song, Guangrong3 ; Liu, Haifeng 1; Shen, Hao 1; Liu, Yuanhua 4; Wang, Yuya 1; Xing, Huayue 1; Zhu, Xiaoyan 1; Hao, Pei 4; Guo, Fan 2; Liu, Xiaolong1
	2018-09-14
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	9
发表状态	已发表
DOI	10.1038/s41467-018-06282-2
摘要	In response to myeloablative stresses, HSCs are rapidly activated to replenish myeloid progenitors, while maintaining full potential of self-renewal to ensure life-long hematopoiesis. However, the key factors that orchestrate HSC activities during physiological stresses remain largely unknown. Here we report that Med23 controls the myeloid potential of activated HSCs. Ablation of Med23 in hematopoietic system leads to lymphocytopenia. Med23-deficient HSCs undergo myeloid-biased differentiation and lose the self-renewal capacity. Interestingly, Med23-deficient HSCs are much easier to be activated in response to physiological stresses. Mechanistically, Med23 plays essential roles in maintaining stemness genes expression and suppressing myeloid lineage genes expression. Med23 is downregulated in HSCs and Med23 deletion results in better survival under myeloablative stress. Altogether, our findings identify Med23 as a gatekeeper of myeloid potential of HSCs, thus providing unique insights into the relationship among Med23-mediated transcriptional regulations, the myeloid potential of HSCs and HSC activation upon stresses.
收录类别	SCI ; SCIE
语种	英语
资助项目	China Postdoctoral Science Foundation[2015M581672]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000444554800003
出版者	NATURE PUBLISHING GROUP
WOS关键词	MEDIATOR MED23 ; SELF-RENEWAL ; PROGENITOR CELLS ; DIFFERENTIATION ; TRANSCRIPTION ; EXPRESSION ; ACTIVATION ; SUBUNIT ; REQUIREMENT ; COMPLEX
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/27778
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_刘小龙组生命科学与技术学院_硕士生
通讯作者	Guo, Fan; Liu, Xiaolong
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,State Key Lab Cel, Shanghai 200031, Peoples R China 2.Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, Dept Obstet & Gynecol, Ctr Translat Med,West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Chen, Xufeng,Zhao, Jingyao,Gu, Chan,et al. Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells[J]. NATURE COMMUNICATIONS,2018,9.
APA	Chen, Xufeng.,Zhao, Jingyao.,Gu, Chan.,Cui, Yu.,Dai, Yuling.,...&Liu, Xiaolong.(2018).Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells.NATURE COMMUNICATIONS,9.
MLA	Chen, Xufeng,et al."Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells".NATURE COMMUNICATIONS 9(2018).