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| Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells | |
| 2018-09-14 | |
| Source Publication | NATURE COMMUNICATIONS
 |
| ISSN | 2041-1723 |
| Volume | 9 |
| Status | 已发表 |
| DOI | 10.1038/s41467-018-06282-2 |
| Abstract | In response to myeloablative stresses, HSCs are rapidly activated to replenish myeloid progenitors, while maintaining full potential of self-renewal to ensure life-long hematopoiesis. However, the key factors that orchestrate HSC activities during physiological stresses remain largely unknown. Here we report that Med23 controls the myeloid potential of activated HSCs. Ablation of Med23 in hematopoietic system leads to lymphocytopenia. Med23-deficient HSCs undergo myeloid-biased differentiation and lose the self-renewal capacity. Interestingly, Med23-deficient HSCs are much easier to be activated in response to physiological stresses. Mechanistically, Med23 plays essential roles in maintaining stemness genes expression and suppressing myeloid lineage genes expression. Med23 is downregulated in HSCs and Med23 deletion results in better survival under myeloablative stress. Altogether, our findings identify Med23 as a gatekeeper of myeloid potential of HSCs, thus providing unique insights into the relationship among Med23-mediated transcriptional regulations, the myeloid potential of HSCs and HSC activation upon stresses. |
| Indexed By | SCI ; SCIE |
| Language | 英语 |
| Funding Project | China Postdoctoral Science Foundation[2015M581672] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000444554800003 |
| Publisher | NATURE PUBLISHING GROUP |
| WOS Keyword | MEDIATOR MED23 ; SELF-RENEWAL ; PROGENITOR CELLS ; DIFFERENTIATION ; TRANSCRIPTION ; EXPRESSION ; ACTIVATION ; SUBUNIT ; REQUIREMENT ; COMPLEX |
| Original Document Type | Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/27778 |
| Collection | 生命科学与技术学院 生命科学与技术学院_特聘教授组_刘小龙组 生命科学与技术学院_硕士生 |
| Corresponding Author | Guo, Fan; Liu, Xiaolong |
| Affiliation | 1.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,State Key Lab Cel, Shanghai 200031, Peoples R China 2.Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, Dept Obstet & Gynecol, Ctr Translat Med,West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Xufeng,Zhao, Jingyao,Gu, Chan,et al. Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells[J]. NATURE COMMUNICATIONS,2018,9. |
| APA | Chen, Xufeng.,Zhao, Jingyao.,Gu, Chan.,Cui, Yu.,Dai, Yuling.,...&Liu, Xiaolong.(2018).Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells.NATURE COMMUNICATIONS,9. |
| MLA | Chen, Xufeng,et al."Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells".NATURE COMMUNICATIONS 9(2018). |
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