Olfactory functional covariance connectivity in Parkinson's disease: Evidence from a Chinese population

doi:10.3389/fnagi.2022.1071520

	Olfactory functional covariance connectivity in Parkinson's disease: Evidence from a Chinese population
	Du, Shouyun 1; Wang, Yiqing 2,3; Li, Guodong 1; Wei, Hongyu 2; Yan, Hongjie 4; Li, Xiaojing 2; Wu, Yijie 2; Zhu, Jianbing 5; Wang, Yi 5; Cai, Zenglin 2,3; Wang, Nizhuan6
	2023-01-04
发表期刊	FRONTIERS IN AGING NEUROSCIENCE (IF:4.1[JCR-2023],4.6[5-Year])
ISSN	1663-4365
卷号	14
发表状态	已发表
DOI	10.3389/fnagi.2022.1071520
摘要	IntroductionCentral anosmia is a potential marker of the prodrome and progression of Parkinson's disease (PD). Resting-state functional magnetic resonance imaging studies have shown that olfactory dysfunction is related to abnormal changes in central olfactory-related structures in patients with early PD. MethodsThis study, which was conducted at Guanyun People's Hospital, analyzed the resting-state functional magnetic resonance data using the functional covariance connection strength method to decode the functional connectivity between the white-gray matter in a Chinese population comprising 14 patients with PD and 13 controls. ResultsThe following correlations were observed in patients with PD: specific gray matter areas related to smell (i.e., the brainstem, right cerebellum, right temporal fusiform cortex, bilateral superior temporal gyrus, right Insula, left frontal pole and right superior parietal lobule) had abnormal connections with white matter fiber bundles (i.e., the left posterior thalamic radiation, bilateral posterior corona radiata, bilateral superior corona radiata and right superior longitudinal fasciculus); the connection between the brainstem [region of interest (ROI) 1] and right cerebellum (ROI2) showed a strong correlation. Right posterior corona radiation (ROI11) showed a strong correlation with part 2 of the Unified Parkinson's Disease Rating Scale, and right superior longitudinal fasciculus (ROI14) showed a strong correlation with parts 1, 2, and 3 of the Unified Parkinson's Disease Rating Scale and Hoehn and Yahr Scale. DiscussionThe characteristics of olfactory-related brain networks can be potentially used as neuroimaging biomarkers for characterizing PD states. In the future, dynamic testing of olfactory function may help improve the accuracy and specificity of olfactory dysfunction in the diagnosis of neurodegenerative diseases.
关键词	Parkinson's disease functional covariance connectivity resting-state fMRI gray matter white matter olfactory function
URL	查看原文
收录类别	SCI ; SCOPUS
语种	英语
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS记录号	WOS:000913913500001
出版者	FRONTIERS MEDIA SA
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/274933
专题	生物医学工程学院_PI研究组_沈定刚组
通讯作者	Cai, Zenglin; Wang, Nizhuan
作者单位	1.Guanyun Cty Peoples Hosp, Dept Neurol, Lianyungang, Peoples R China 2.Nanjing Univ, Affiliated Suzhou Hosp, Med Sch, Dept Neurol, Suzhou, Peoples R China 3.Nanjing Med Univ, Suzhou Sci & Technol Town Hosp, Gusu Sch, Dept Neurol, Suzhou, Peoples R China 4.Xuzhou Med Univ, Affiliated Lianyungang Hosp, Dept Neurol, Lianyungang, Peoples R China 5.Nanjing Univ, Affiliated Suzhou Hosp, Med Sch, Dept Radiol, Suzhou, Peoples R China 6.ShanghaiTech Univ, Sch Biomed Engn, Shanghai, Peoples R China
通讯作者单位	生物医学工程学院
推荐引用方式 GB/T 7714	Du, Shouyun,Wang, Yiqing,Li, Guodong,et al. Olfactory functional covariance connectivity in Parkinson's disease: Evidence from a Chinese population[J]. FRONTIERS IN AGING NEUROSCIENCE,2023,14.
APA	Du, Shouyun.,Wang, Yiqing.,Li, Guodong.,Wei, Hongyu.,Yan, Hongjie.,...&Wang, Nizhuan.(2023).Olfactory functional covariance connectivity in Parkinson's disease: Evidence from a Chinese population.FRONTIERS IN AGING NEUROSCIENCE,14.
MLA	Du, Shouyun,et al."Olfactory functional covariance connectivity in Parkinson's disease: Evidence from a Chinese population".FRONTIERS IN AGING NEUROSCIENCE 14(2023).