Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes

doi:10.1016/j.stem.2018.05.022

	Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes
	Deng, Xing 1; Zhang, Xin 1; Li, Weiping 2,3; Feng, Ren-Xin 1; Li, Lu 2,3; Yi, Gui-Rong 1; Zhang, Xiao-Nan 1; Yin, Chuan 1; Yu, Hong-Yu 4; Zhang, Jun-Ping 5; Lu, Bin 5; Hui, Lijian2,3,6 ; Xie, Wei-Fen 1,7
	2018-07-05
发表期刊	CELL STEM CELL (IF:19.8[JCR-2023],22.6[5-Year])
ISSN	1934-5909
卷号	23 期号:1 页码:114-+
发表状态	已发表
DOI	10.1016/j.stem.2018.05.022
摘要	Chronic liver injury can cause cirrhosis and impaired liver regeneration, impairing organ function. Adult livers can regenerate in response to parenchymal insults, and multiple cellular sources have been reported to contribute to this response. In this study, we modeled human chronic liver injuries, in which such responses are blunted, without genetic manipulations, and assessed potential contributions of non-parenchymal cells (NPCs) to hepatocyte regeneration. We show that NPC-derived hepatocytes replenish a large fraction of the liver parenchyma following severe injuries induced by long-term thioacetamide (TAA) or 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) treatment. Through lineage tracing of biliary epithelial cells (BECs), we show that BECs are a source of new hepatocytes and gain an Hnf4 alpha(+)CK19(+) bi-phenotypic state in periportal regions and fibrotic septa. Bi-phenotypic cells were also detected in cirrhotic human livers. Together, these data provide further support for hepatocyte regeneration from BECs without genetic interventions and show their cellular plasticity during severe liver injury.
收录类别	SCI ; SCIE
语种	英语
资助项目	External Cooperation Program of BIC, Chinese Academy of Science[XDA16020201] ; External Cooperation Program of BIC, Chinese Academy of Science[153D31KYSB20150085]
WOS研究方向	Cell Biology
WOS类目	Cell & Tissue Engineering ; Cell Biology
WOS记录号	WOS:000438144700018
出版者	CELL PRESS
WOS关键词	STEM-CELLS ; MOUSE MODEL ; REGENERATION ; DIFFERENTIATION ; THIOACETAMIDE ; CIRRHOSIS ; FIBROSIS ; DISEASE ; MICE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/27414
专题	生命科学与技术学院_特聘教授组_惠利健组
通讯作者	Hui, Lijian; Xie, Wei-Fen
作者单位	1.Second Mil Med Univ, Changzheng Hosp, Dept Gastroenterol, Shanghai 200003, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Second Mil Med Univ, Changzheng Hosp, Dept Pathol, Shanghai 200003, Peoples R China 5.Second Mil Med Univ, Sch Pharm, Dept Biochem Pharmacol, Shanghai 200433, Peoples R China 6.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 7.Minist Educ, Key Lab Signaling Regulat & Targeting Therapy Liv, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Deng, Xing,Zhang, Xin,Li, Weiping,et al. Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes[J]. CELL STEM CELL,2018,23(1):114-+.
APA	Deng, Xing.,Zhang, Xin.,Li, Weiping.,Feng, Ren-Xin.,Li, Lu.,...&Xie, Wei-Fen.(2018).Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes.CELL STEM CELL,23(1),114-+.
MLA	Deng, Xing,et al."Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes".CELL STEM CELL 23.1(2018):114-+.