High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption

doi:10.1038/s42255-022-00687-6

	High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption
	Zhong, Wuling 1; Wang, Hui 1; Yang, Yale 1; Zhang, Yali 1; Lai, Hejin 1; Cheng, Yalan 1; Yu, Huimin 1; Feng, Ning 1; Huang, Rui 1; Liu, Shen 2; Yang, Sheng 3; Hao, Tongyang 4; Zhang, Baoyu 4; Ying, Hao 1; Zhang, Fang 5; Guo, Feifan 6; Zhai, Qiwei1,7
	2022-12-01
发表期刊	NATURE METABOLISM (IF:18.9[JCR-2023],21.0[5-Year])
EISSN	2522-5812
卷号	4 期号:12
发表状态	已发表
DOI	10.1038/s42255-022-00687-6
摘要	Dietary restriction is widely used to reduce fat mass and lose weight in individuals with or without obesity; however, weight regain after dieting is still a big challenge, and the underlying mechanisms remain largely elusive. Here we show that refeeding after various types of dieting induces quick fat accumulation in mice and enhanced intestinal lipid absorption contributes to post-dieting fat mass increase. Moreover, refeeding after short-term dietary restriction is accompanied by an increase in intestinal Lactobacillus and its metabolites, which contributes to enhanced intestinal lipid absorption and post-dieting fat mass increase; however, refeeding a high-protein diet after short-term dietary restriction attenuates intestinal lipid absorption and represses fat accumulation by preventing Lactobacillus growth. Our results provide insight into the mechanisms underlying fat mass increase after dieting. We also propose that targeting intestinal Lactobacillus to inhibit intestinal lipid absorption via high-protein diet or antibiotics is likely an effective strategy to prevent obesity after dieting.
URL	查看原文
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China["31630037","91740103","91940306","32200969"] ; National Key R&D Program of China[2018YFA0800603] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19030103] ; Frontier Science of Chinese Academy of Sciences Key Research Projects[QYZDJ-SSW-SMC022] ; China Postdoctoral Science Foundation[2019M661658]
WOS研究方向	Endocrinology & Metabolism
WOS类目	Endocrinology & Metabolism
WOS记录号	WOS:000898698200001
出版者	NATURE PORTFOLIO
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/268664
专题	生命科学与技术学院_特聘教授组_翟琦巍组
通讯作者	Zhai, Qiwei
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Nutr Metab & Food Safety, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Sch Med, Dept Orthopaed, Shanghai, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, Key Lab Synthet Biol, Shanghai, Peoples R China 4.GemPharmatech Co, Nanjing, Peoples R China 5.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Natl Clin Res Ctr Eye Dis, Sch Med, Shanghai, Peoples R China 6.Fudan Univ, Zhongshan Hosp, Inst Translat Brain Res, Minist Educ,Frontiers Ctr Brain Sci,State Key Lab, Shanghai, Peoples R China 7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhong, Wuling,Wang, Hui,Yang, Yale,et al. High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption[J]. NATURE METABOLISM,2022,4(12).
APA	Zhong, Wuling.,Wang, Hui.,Yang, Yale.,Zhang, Yali.,Lai, Hejin.,...&Zhai, Qiwei.(2022).High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption.NATURE METABOLISM,4(12).
MLA	Zhong, Wuling,et al."High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption".NATURE METABOLISM 4.12(2022).