Cytoophidia Maintain the Integrity of Drosophila Follicle Epithelium

doi:10.3390/ijms232315282

	Cytoophidia Maintain the Integrity of Drosophila Follicle Epithelium
	Wang, Qiao-Qi1 ; You, Dong-Dong1 ; Liu, Ji-Long1,2
	2022-12-01
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (IF:4.9[JCR-2023],5.6[5-Year])
EISSN	1422-0067
卷号	23 期号:23
发表状态	已发表
DOI	10.3390/ijms232315282
摘要	CTP synthase (CTPS) forms a filamentous structure termed the cytoophidium in all three domains of life. The female reproductive system of Drosophila is an excellent model for studying the physiological function of cytoophidia. Here, we use CTPSH355A, a point mutation that destroys the cytoophidium-forming ability of CTPS, to explore the in vivo function of cytoophidia. In CTPSH355A egg chambers, we observe the ingression and increased heterogeneity of follicle cells. In addition, we find that the cytoophidium-forming ability of CTPS, rather than the protein level, is the cause of the defects observed in CTPSH355A mutants. To sum up, our data indicate that cytoophidia play an important role in maintaining the integrity of follicle epithelium.
关键词	CTP synthase cytoophidium Drosophila epithelium follicle cell ingression
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收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[2021YFA0804700] ; Shanghai Science and Technology Commission[31771490] ; UK Medical Research Council[20JC1410500] ; Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at ShanghaiTech University["MC_UU_12021/3","MC_U137788471"]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000897479400001
出版者	MDPI
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/266610
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_刘冀珑组生命科学与技术学院_硕士生
通讯作者	Liu, Ji-Long
作者单位	1.Shanghai Technol Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Qiao-Qi,You, Dong-Dong,Liu, Ji-Long. Cytoophidia Maintain the Integrity of Drosophila Follicle Epithelium[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(23).
APA	Wang, Qiao-Qi,You, Dong-Dong,&Liu, Ji-Long.(2022).Cytoophidia Maintain the Integrity of Drosophila Follicle Epithelium.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(23).
MLA	Wang, Qiao-Qi,et al."Cytoophidia Maintain the Integrity of Drosophila Follicle Epithelium".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.23(2022).