Generation of two iPSC cell lines (SIAISi020-A and SIAISi019-A) from an 82-year-old mild cognitive impairment (MCI) and her unaffected child from Chinese Han population

doi:10.1016/j.scr.2022.102869

	Generation of two iPSC cell lines (SIAISi020-A and SIAISi019-A) from an 82-year-old mild cognitive impairment (MCI) and her unaffected child from Chinese Han population
	Ding, Yanfei 1,2,3; Chen, Haijuan 1,2,3; Zhao, Jian4,5 ; Wang, Ying4,5 ; Deng, Yulei 1,2,3
	2022-08-01
发表期刊	STEM CELL RESEARCH (IF:0.8[JCR-2023],1.1[5-Year])
ISSN	1873-5061
EISSN	1876-7753
卷号	63
发表状态	已发表
DOI	10.1016/j.scr.2022.102869
摘要	IPSCs have great potential value in cell replacement therapy, pathogenesis research, screening for new drugs, and treatment of clinical disease. An 82-year-old woman with mild cognitive impairment (MCI) and her unaffected child donated their peripheral blood mononuclear cells (PBMC). Their PBMCs were reprogrammed using human OKSM transcription factors (SOX2, OCT3/4, KLF4 and C-MYC) via a non-integrated complementary vector system. In the newly developed hiPSC series SIAISi019-A and SIAISi020-A, immunocytochemistry and the ability to spontaneously differentiate into 3 germ layers in vitro confirmed the pluripotency of transgene-free iPSCs. And their karyotypes were normal.
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收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82171400] ; Natural Science Foundation of Shanghai[19ZR1432500]
WOS研究方向	Cell Biology ; Biotechnology & Applied Microbiology
WOS类目	Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology
WOS记录号	WOS:000885889600011
出版者	ELSEVIER
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/266594
专题	生命科学与技术学院免疫化学研究所_PI研究组_赵简组
通讯作者	Wang, Ying; Deng, Yulei
作者单位	1.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Neurol, Sch Med,Luwan Branch, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Neurol, Shanghai, Peoples R China 3.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Inst Neurol, Shanghai, Peoples R China 4.ShanghaiTech, Shanghai Inst Adv Immunochem Studies, Lab Regenerat Med & Neural Repair, Shanghai, Peoples R China 5.ShanghaiTech, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	免疫化学研究所; 生命科学与技术学院
推荐引用方式 GB/T 7714	Ding, Yanfei,Chen, Haijuan,Zhao, Jian,et al. Generation of two iPSC cell lines (SIAISi020-A and SIAISi019-A) from an 82-year-old mild cognitive impairment (MCI) and her unaffected child from Chinese Han population[J]. STEM CELL RESEARCH,2022,63.
APA	Ding, Yanfei,Chen, Haijuan,Zhao, Jian,Wang, Ying,&Deng, Yulei.(2022).Generation of two iPSC cell lines (SIAISi020-A and SIAISi019-A) from an 82-year-old mild cognitive impairment (MCI) and her unaffected child from Chinese Han population.STEM CELL RESEARCH,63.
MLA	Ding, Yanfei,et al."Generation of two iPSC cell lines (SIAISi020-A and SIAISi019-A) from an 82-year-old mild cognitive impairment (MCI) and her unaffected child from Chinese Han population".STEM CELL RESEARCH 63(2022).