A new deuterium-labeled compound [2,3,4,6,6'-2H5]-D-glucose for deuterium magnetic resonance metabolic imaging

doi:10.1002/nbm.4890

	A new deuterium-labeled compound [2,3,4,6,6'-2H5]-D-glucose for deuterium magnetic resonance metabolic imaging
	Zou, Chao1,2,3 ; Ruan, Yingheng 4; Li, Huanxi 4; Wan, Qian 1; Du, Feng 1; Yuan, Jiawen 1,5; Qin, Qikai6,7 ; Thompson, Garth J.6 ; Yang, Xiaojun 4; Li, Ye 1,2,3,8; Liu, Xin 1,2,3; Zheng, Hairong 1,3
	2022-12-07
发表期刊	NMR IN BIOMEDICINE (IF:2.7[JCR-2023],3.2[5-Year])
ISSN	0952-3480
EISSN	1099-1492
卷号	36 期号:7
发表状态	已发表
DOI	10.1002/nbm.4890
摘要	Deuterium (H-2) magnetic resonance imaging is an emerging approach for noninvasively studying glucose metabolism in vivo, which is important for understanding pathogenesis and monitoring the progression of many diseases such as tumors, diabetes, and neurodegenerative diseases. However, the synthesis of H-2-labeled glucose is costly because of the expensive raw substrates and the requirement for extreme reaction conditions, making the H-2-labeled glucose rather expensive and unaffordable for clinic use. In this study, we present a new deuterated compound, [2,3,4,6,6'-H-2(5)]-D-glucose, with an approximate 10-fold reduction in production costs. The synthesis route uses cheaper raw substrate methyl-alpha-D-glucopyranoside, relies on mild reaction conditions (80 degrees C), and has higher deuterium labeling efficiency. Magnetic resonance spectroscopy (MRS) and mass spectroscopy experiments confirmed the successful deuterium labeling in the compound. Animal studies demonstrated that the substrate could describe the glycolytic metabolism in a glioma rat model by quantifying the downstream metabolites through H-2-MRS on an ultrahigh field system. Comparison of the glucose metabolism characteristics was carried out between [2,3,4,6,6'-H-2(5)]-D-glucose and commercial [6,6'-H-2(2)]-D-glucose in the animal studies. This cost-effective compound will help facilitate the clinical translation of deuterium magnetic resonance imaging, and enable this powerful metabolic imaging modality to be widely used in both preclinical and clinical research and applications.
关键词	deuterium magnetic resonance imaging deuterated glucose glioma
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收录类别	SCI ; EI
语种	英语
资助项目	National Key Research Program of China["2022YFA1004203","2021YFE0204400","2021YFF0501500"] ; Shenzhen Municipal Scientific Program["JCY20200109110612375","RCYX20200714114735123"] ; Scientific Instrument Innovation Team of the Chinese Academy of sciences[GJJSTD20180002] ; Strategic Priority Research Program of Chinese Academy of sciences[XDB25000000] ; Key Laboratory Project of Guangdong Province[2020B1212060051] ; Innovation Promotion Association of Chinese Academy of Sciences[Y2021098]
WOS研究方向	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS类目	Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
WOS记录号	WOS:000905584100001
出版者	WILEY
EI入藏号	20230113335461
EI主题词	Glucose
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 701.2 Magnetism: Basic Concepts and Phenomena ; 746 Imaging Techniques ; 804.1 Organic Compounds ; 911.2 Industrial Economics
原始文献类型	Journal article (JA)
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/263284
专题	生命科学与技术学院_博士生 iHuman研究所_PI研究组_Garth John Thompson组
通讯作者	Li, Ye
作者单位	1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Paul C Lauterbur Res Ctr Biomed Imaging, Shenzhen, Guangdong, Peoples R China 2.Key Lab Magnet Resonance & Multimodal Imaging Guan, Shenzhen, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Shenzhen Dingbang Biosci Co Ltd, Shenzhen, Guangdong, Peoples R China 5.Southern Univ Sci & Technol, Shenzhen, Guangdong, Peoples R China 6.Shanghai Tech Univ, iHuman Inst, Shanghai, Peoples R China 7.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 8.Chinese Acad Sci, Shenzhen Inst Adv Technol, Paul C Lauterbur Res Ctr Biomed Imaging, 1068 Xueyuan Ave, Shenzhen 518055, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zou, Chao,Ruan, Yingheng,Li, Huanxi,et al. A new deuterium-labeled compound [2,3,4,6,6'-2H5]-D-glucose for deuterium magnetic resonance metabolic imaging[J]. NMR IN BIOMEDICINE,2022,36(7).
APA	Zou, Chao.,Ruan, Yingheng.,Li, Huanxi.,Wan, Qian.,Du, Feng.,...&Zheng, Hairong.(2022).A new deuterium-labeled compound [2,3,4,6,6'-2H5]-D-glucose for deuterium magnetic resonance metabolic imaging.NMR IN BIOMEDICINE,36(7).
MLA	Zou, Chao,et al."A new deuterium-labeled compound [2,3,4,6,6'-2H5]-D-glucose for deuterium magnetic resonance metabolic imaging".NMR IN BIOMEDICINE 36.7(2022).