Anti-IgLON5 disease: a novel topic beyond neuroimmunology

doi:10.4103/1673-5374.355742

	Anti-IgLON5 disease: a novel topic beyond neuroimmunology
	Zhang, Yi-Zong 1,2; Ni, You 1,2; Gao, Yi-Ning 1,2; Shen, Ding-Ding 1,2,3; He, Lu 1,2; Yin, Dou 1,2; Meng, Huan-Yu 1,2; Zhou, Qin-Ming 1,2; Hu, Ji2,3,4,5 ; Chen, Sheng 1,2
	2023-05-01
发表期刊	NEURAL REGENERATION RESEARCH (IF:5.9[JCR-2023],5.2[5-Year])
ISSN	1673-5374
EISSN	1876-7958
卷号	18 期号:5
发表状态	已发表
DOI	10.4103/1673-5374.355742
摘要	Anti-IgLON5 disease is a recently defined autoimmune disorder of the nervous system associated with autoantibodies against IgLON5. Given its broad clinical spectrum and extremely complex pathogenesis, as well as difficulties in its early diagnosis and treatment, anti-IgLON5 disease has become the subject of considerable research attention in the field of neuroimmunology. Anti-IgLON5 disease has characteristics of both autoimmunity and neurodegeneration due to the unique activity of the anti-IgLON5 antibody. Neuropathologic examination revealed the presence of a tauopathy preferentially affecting the hypothalamus and brainstem tegmentum, potentially broadening our understanding of tauopathies. In contrast to that seen with other autoimmune encephalitis-related antibodies, basic studies have demonstrated that IgLON5 antibody-induced neuronal damage and degeneration are irreversible, indicative of a potential link between autoimmunity and neurodegeneration in anti-IgLON5 disease. Herein, we comprehensively review and discuss basic and clinical studies relating to anti-IgLON5 disease to better understand this complicated disorder.
关键词	anti-IgLON5 disease autoimmune encephalitis human leukocyte antigen IgG4-related diseases IgLON5 antibody IgLONs immunotherapy inflammation neurodegeneration neuroimmunology tauopathy
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收录类别	SCI ; SCOPUS
语种	英语
资助项目	Shanghai Shuguang Plan Project[18SG15] ; Shanghai Talent Development Project[2019044] ; Clinical Research Plan of SHDC[SHDC 2020CR2027B]
WOS研究方向	Cell Biology ; Neurosciences & Neurology
WOS类目	Cell Biology ; Neurosciences
WOS记录号	WOS:000884915500013
出版者	WOLTERS KLUWER MEDKNOW PUBLICATIONS
Scopus 记录号	2-s2.0-85140233913
来源库	Scopus
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/251703
专题	生命科学与技术学院_PI研究组_胡霁组
通讯作者	Zhou, Qin-Ming; Hu, Ji; Chen, Sheng
作者单位	1.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Neurol, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Inst Neurol, Sch Med, Shanghai, Peoples R China 3.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Jiangsu, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 5.Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Yi-Zong,Ni, You,Gao, Yi-Ning,et al. Anti-IgLON5 disease: a novel topic beyond neuroimmunology[J]. NEURAL REGENERATION RESEARCH,2023,18(5).
APA	Zhang, Yi-Zong.,Ni, You.,Gao, Yi-Ning.,Shen, Ding-Ding.,He, Lu.,...&Chen, Sheng.(2023).Anti-IgLON5 disease: a novel topic beyond neuroimmunology.NEURAL REGENERATION RESEARCH,18(5).
MLA	Zhang, Yi-Zong,et al."Anti-IgLON5 disease: a novel topic beyond neuroimmunology".NEURAL REGENERATION RESEARCH 18.5(2023).