Melanopsin retinal ganglion cells mediate light-promoted brain development

doi:10.1016/j.cell.2022.07.009

	Melanopsin retinal ganglion cells mediate light-promoted brain development
	Hu, Jiaxi 1; Shi, Yiming 1; Zhang, Jiaming 1; Huang, Xinfeng 1; Wang, Qian 1; Zhao, Hang 1; Shen, Jiawei 1; Chen, Zhiping 1; Song, Wei 2; Zheng, Ping 2; Zhan, Shulu3 ; Sun, Yanping 1; Cai, Pengfei 1; An, Kai 1; Ouyang, Changjie 1; Zhao, Baizhen 4,5; Zhou, Qixin 4,5; Xu, Lin 4,5; Xiong, Wei 1; Zhang, Zhi 1; Meng, Jianjun 1; Chen, Jutao 1; Ma, Yuqian 1; Zhao, Huan 1; Zhang, Mei 1; Qu, Kun 1; Hu, Ji3 ; Luo, Minhua 6; Xu, Fuqiang 7; Chen, Xiaowei 8,9; Xiong, Ying 1; Bao, Jin 1; Xue, Tian 1
	2022-08-18
发表期刊	CELL (IF:45.5[JCR-2023],49.0[5-Year])
ISSN	0092-8674
EISSN	1097-4172
卷号	185 期号:17
发表状态	已发表
DOI	10.1016/j.cell.2022.07.009
摘要	During development, melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) become light sensitive much earlier than rods and cones. IpRGCs project to many subcortical areas, whereas physiological functions of these projections are yet to be fully elucidated. Here, we found that ipRGC-medi-ated light sensation promotes synaptogenesis of pyramidal neurons in various cortices and the hippocam-pus. This phenomenon depends on activation of ipRGCs and is mediated by the release of oxytocin from the supraoptic nucleus (SON) and the paraventricular nucleus (PVN) into cerebral-spinal fluid. We further characterized a direct connection between ipRGCs and oxytocin neurons in the SON and mutual projections between oxytocin neurons in the SON and PVN. Moreover, we showed that the lack of ipRGC-mediated, light -promoted early cortical synaptogenesis compromised learning ability in adult mice. Our results highlight the importance of light sensation early in life on the development of learning ability and therefore call attention to suitable light environment for infant care.
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收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000877930800001
出版者	CELL PRESS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/248885
专题	生命科学与技术学院_PI研究组_胡霁组生命科学与技术学院_博士生
通讯作者	Bao, Jin; Xue, Tian
作者单位	1.Univ Sci & Technol China, Hefei Natl Res Ctr Phys Sci Microscale, CAS Key Lab Brain Funct & Dis,Sch Life Sci, Biomed Sci & Hlth Lab Anhui Prov,Div Life Sci & M, Hefei 230026, Peoples R China 2.Tech Ctr Hefei Customs, Hefei 230029, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Lab Learning & Memory,KIZ SU Joint Lab Anim Model, Kunming 650223, Yunnan, Peoples R China 5.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China 6.Chinese Acad Sci, Wuhan Inst Virol, CAS Ctr Excellence Brain Sci & Intelligence Techn, Ctr Biosafety Mega Sci,State Key Lab Virol, Wuhan 430071, Peoples R China 7.Chinese Acad Sci, Shenzhen Inst Adv Technol,Brain Connectome & Beha, Brain Cognit & Brain Dis Inst,CAS Key Lab Brain C, Shenzhen Hong Kong Inst Brain Sci Shenzhen Fundam, Shenzhen 518055, Peoples R China 8.Third Mil Med Univ, Brain Res Ctr, Chongqing 400038, Peoples R China 9.Chongqing Inst Brain & Intelligence, Guangyang Bay Lab, Chongqing 400038, Peoples R China
推荐引用方式 GB/T 7714	Hu, Jiaxi,Shi, Yiming,Zhang, Jiaming,et al. Melanopsin retinal ganglion cells mediate light-promoted brain development[J]. CELL,2022,185(17).
APA	Hu, Jiaxi.,Shi, Yiming.,Zhang, Jiaming.,Huang, Xinfeng.,Wang, Qian.,...&Xue, Tian.(2022).Melanopsin retinal ganglion cells mediate light-promoted brain development.CELL,185(17).
MLA	Hu, Jiaxi,et al."Melanopsin retinal ganglion cells mediate light-promoted brain development".CELL 185.17(2022).