Ca(v)2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization

doi:10.1038/s41419-022-05174-0

	Ca(v)2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization
	Xue, Ying 1,2; Li, Min 1,2; Hu, Jie 3; Song, Yuanlin 3; Guo, Wei 4; Miao, Changhong 1,5; Di Ge 6; Hou, Yingyong 7; Wang, Xuefei 8; Huang, Xingxu9 ; Liu, Tianshu 1,10; Zhang, Xiaoping 11; Huang, Qihong 1,2,12
	2022-09-22
发表期刊	CELL DEATH & DISEASE (IF:8.1[JCR-2023],8.6[5-Year])
ISSN	2041-4889
卷号	13 期号:9
DOI	10.1038/s41419-022-05174-0
摘要	Distant metastasis is the main cause of mortality in breast cancer patients. Using the breast cancer genomic data from The Cancer Genome Atlas (TCGA), we identified brain specific Ca(v)2.2 as a critical regulator of metastasis. Ca(v)2.2 expression is significantly upregulated in breast cancer and its higher expression is inversely correlated with survival suggesting a previously unappreciated role of Ca(v)2.2 in breast cancer. Ca(v)2.2 is required for breast cancer migration, invasion, and metastasis. Interestingly, Ca(v)2.2 promotes invadopodia formation and extracellular matrix (ECM) degradation through the stabilization of invadopodia component cortactin in a proteosome-dependent manner. Moreover, deubiquitinating enzyme USP43 mediated the functions of Ca(v)2.2 in cortactin stabilization, invadopodia formation, ECM degradation, and metastasis. Interestingly, Ca(v)2.2 upregulates USP43 expression through NFAT2 dephosphorylation and nuclear localization. Our study uncovered a novel pathway that regulates cortactin expression and invadopodia formation in breast cancer metastasis.
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收录类别	SCIE
语种	英语
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000856970000001
出版者	SPRINGERNATURE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/243186
专题	生命科学与技术学院_PI研究组_黄行许组
通讯作者	Zhang, Xiaoping; Huang, Qihong
作者单位	1.Fudan Univ, Zhongshan Hosp, Canc Ctr, Shanghai, Peoples R China; 2.Fudan Univ, Zhongshan Hosp, Inst Clin Sci, Shanghai, Peoples R China; 3.Fudan Univ, Zhongshan Hosp, Dept Pulm & Crit Care Med, Shanghai, Peoples R China; 4.Fudan Univ, Zhongshan Hosp, Dept Lab Med, Shanghai, Peoples R China; 5.Fudan Univ, Zhongshan Hosp, Dept Anesthesiol, Shanghai, Peoples R China; 6.Fudan Univ, Zhongshan Hosp, Dept Thorac Surg, Shanghai, Peoples R China; 7.Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai, Peoples R China; 8.Fudan Univ, Zhongshan Hosp, Dept Gen Surg, Gastr Canc Ctr, Shanghai, Peoples R China; 9.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China; 10.Fudan Univ, Zhongshan Hosp, Dept Med Oncol, Shanghai, Peoples R China; 11.Tongji Univ, Inst Intervent Vessel, Sch Med, Shanghai, Peoples R China; 12.Shanghai Resp Res Inst, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Xue, Ying,Li, Min,Hu, Jie,et al. Ca(v)2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization[J]. CELL DEATH & DISEASE,2022,13(9).
APA	Xue, Ying.,Li, Min.,Hu, Jie.,Song, Yuanlin.,Guo, Wei.,...&Huang, Qihong.(2022).Ca(v)2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization.CELL DEATH & DISEASE,13(9).
MLA	Xue, Ying,et al."Ca(v)2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization".CELL DEATH & DISEASE 13.9(2022).