Estimation of acute oral toxicity in rat using local lazy learning

doi:10.1186/1758-2946-6-26

	Estimation of acute oral toxicity in rat using local lazy learning
	Lu, Jing 1,2; Peng, Jianlong 2; Wang, Jinan 2; Shen, Qiancheng 2; Bi, Yi 1; Gong, Likun 2; Zheng, Mingyue 2; Luo, Xiaomin 2; Zhu, Weiliang 2; Jiang, Hualiang2,3,4 ; Chen, Kaixian2,3
	2014-05-16
发表期刊	JOURNAL OF CHEMINFORMATICS (IF:7.1[JCR-2023],9.3[5-Year])
ISSN	1758-2946
卷号	6
发表状态	已发表
DOI	10.1186/1758-2946-6-26
摘要	Background: Acute toxicity means the ability of a substance to cause adverse effects within a short period following dosing or exposure, which is usually the first step in the toxicological investigations of unknown substances. The median lethal dose, LD50, is frequently used as a general indicator of a substance's acute toxicity, and there is a high demand on developing non-animal-based prediction of LD50. Unfortunately, it is difficult to accurately predict compound LD50 using a single QSAR model, because the acute toxicity may involve complex mechanisms and multiple biochemical processes.
关键词	Acute toxicity Local lazy learning Applicability domain Consensus model
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81220108025] ; National Natural Science Foundation of China[81001399] ; National Natural Science Foundation of China[2013ZX09507001]
WOS研究方向	Chemistry ; Computer Science
WOS类目	Chemistry, Multidisciplinary ; Computer Science, Information Systems ; Computer Science, Interdisciplinary Applications
WOS记录号	WOS:000336991100001
出版者	BMC
WOS关键词	PLASMA-PROTEIN BINDING ; APPLICABILITY DOMAIN ; QSAR ; PREDICTION ; MODELS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2402
专题	免疫化学研究所_特聘教授组_蒋华良组生命科学与技术学院_特聘教授组_陈凯先组
通讯作者	Zheng, Mingyue
作者单位	1.Yantai Univ, Sch Pharm, Dept Med Chem, Yantai 264005, Shandong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Drug Discovery & Design Ctr, Shanghai 201203, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 4.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
推荐引用方式 GB/T 7714	Lu, Jing,Peng, Jianlong,Wang, Jinan,et al. Estimation of acute oral toxicity in rat using local lazy learning[J]. JOURNAL OF CHEMINFORMATICS,2014,6.
APA	Lu, Jing.,Peng, Jianlong.,Wang, Jinan.,Shen, Qiancheng.,Bi, Yi.,...&Chen, Kaixian.(2014).Estimation of acute oral toxicity in rat using local lazy learning.JOURNAL OF CHEMINFORMATICS,6.
MLA	Lu, Jing,et al."Estimation of acute oral toxicity in rat using local lazy learning".JOURNAL OF CHEMINFORMATICS 6(2014).