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Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway | |
2018-05 | |
发表期刊 | PLOS PATHOGENS
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ISSN | 1553-7366 |
卷号 | 14期号:5 |
发表状态 | 已发表 |
DOI | 10.1371/journal.ppat.1007075 |
摘要 | Toll-like receptor 3 (TLR3) senses dsRNA intermediates produced during RNA virus replication to activate innate immune signaling pathways through adaptor protein TRIF. Many viruses have evolved strategies to block TLR3-mediated interferon signaling via targeting TRIF. Here we studied how hepatitis C virus (HCV) antagonizes the TLR3-mediated interferon signaling. We found that HCV-encoded NS4B protein inhibited TLR3-mediated interferon signaling by down-regulating TRIF protein level. Mechanism studies indicated that the downregulation of TRIF by NS4B was dependent on caspase8. NS4B transfection or HCV infection can activate caspase8 to promote TRIF degradation, leading to suppression of TLR3-mediated interferon signaling. Knockout of caspase8 can prevent TRIF degradation triggered by NS4B, thereby enhancing the TLR3-mediated interferon signaling activation in response to HCV infection. In conclusion, our work revealed a new mechanism for HCV to evade innate immune response by blocking the TLR3-mediated interferon signaling via NS4B-induced TRIF degradation. |
收录类别 | SCI ; SCIE |
资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDPB03] |
WOS研究方向 | Microbiology ; Parasitology ; Virology |
WOS类目 | Microbiology ; Parasitology ; Virology |
WOS记录号 | WOS:000434026400052 |
出版者 | PUBLIC LIBRARY SCIENCE |
WOS关键词 | TOLL-LIKE RECEPTOR-3 ; DOUBLE-STRANDED-RNA ; DOMAIN-CONTAINING ADAPTER ; RIG-I ; INNATE IMMUNITY ; BETA PRODUCTION ; RECOGNITION ; PROTEIN ; ACTIVATION ; REQUIRES |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/23067 |
专题 | 生命科学与技术学院 生命科学与技术学院_特聘教授组_钟劲组 生命科学与技术学院_博士生 |
共同第一作者 | Cao, Xuezhi |
通讯作者 | Zhong, Jin |
作者单位 | 1.Chinese Acad Sci, Inst Pasteur Shanghai, Unit Viral Hepatitis, CAS Key Lab Mol Virol & Immunol, Shanghai, Peoples R China 2.ShanghaiTech Univ, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
第一作者单位 | 上海科技大学 |
通讯作者单位 | 上海科技大学 |
推荐引用方式 GB/T 7714 | Liang, Yisha,Cao, Xuezhi,Ding, Qiang,et al. Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway[J]. PLOS PATHOGENS,2018,14(5). |
APA | Liang, Yisha,Cao, Xuezhi,Ding, Qiang,Zhao, Yanan,He, Zhenliang,&Zhong, Jin.(2018).Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway.PLOS PATHOGENS,14(5). |
MLA | Liang, Yisha,et al."Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway".PLOS PATHOGENS 14.5(2018). |
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