Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo

doi:10.1002/dvdy.530

	Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo
	Zhao, Junzheng1,2,3 ; Zhao, Jingjie1
	2022-09
发表期刊	DEVELOPMENTAL DYNAMICS (IF:2.0[JCR-2023],2.7[5-Year])
ISSN	1058-8388
EISSN	1097-0177
发表状态	已发表
DOI	10.1002/dvdy.530
摘要	Background Genomic and epigenomic dynamics both play critical roles during embryogenesis. Zfp57 maintains genomic imprinting with both maternal and zygotic functions. In our previous study, we found that maternal and zygotic Zfp57 modulate NOTCH signaling during cardiac development. In this study, we investigated Zfp57 mutants from E11.5 to E13.5 to delineate its function during cardiac development. Results Here, we describe novel roles of maternal and zygotic Zfp57 during cardiovascular system development. We found that maternal and zygotic Zfp57 was required for coronary vascular development. Maternal and zygotic loss of Zfp57 perturbed the sprouting of the sinus venosus-derived endothelial cells and led to underdeveloped coronary vasculature, meanwhile, there was an ectopic overproduction of blood islands over the ventricles. Furthermore, loss of Zfp57 and failed vasculature disturbed myocardium maturation. Loss of maternal and zygotic Zfp57 resulted in hyper trabeculation and failed myocardium compaction. Zfp57 zygotic mutant (M(+)Z(-)) hearts displayed noncompaction cardiomyopathy at E18.5. Conclusions Our results suggest that maternal and zygotic ZFP57 are essential for coronary vascular formation and myocardium maturation in mice. Our research provides evidence for the role of genomic imprinting during embryogenesis.
关键词	cardiac development coronary vasculature genomic imprinting noncompaction ZFP57
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Anatomy & Morphology ; Developmental Biology
WOS类目	Anatomy & Morphology ; Developmental Biology
WOS记录号	WOS:000852243300001
出版者	WILEY
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/229826
专题	生命科学与技术学院_博士生生命科学与技术学院_硕士生
通讯作者	Zhao, Junzheng
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhao, Junzheng,Zhao, Jingjie. Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo[J]. DEVELOPMENTAL DYNAMICS,2022.
APA	Zhao, Junzheng,&Zhao, Jingjie.(2022).Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo.DEVELOPMENTAL DYNAMICS.
MLA	Zhao, Junzheng,et al."Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo".DEVELOPMENTAL DYNAMICS (2022).