Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria

doi:10.1016/j.redox.2014.12.011

	Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria
	Zhong, Huiqin 1,2,3; Yin, Huiyong1,2,3,4
	2015-04
发表期刊	REDOX BIOLOGY (IF:10.7[JCR-2023],11.7[5-Year])
ISSN	2213-2317
卷号	4 页码:193-199
发表状态	已发表
DOI	10.1016/j.redox.2014.12.011
摘要	Oxidative stress-induced lipid peroxidation has been associated with human physiology and diseases including cancer. Overwhelming data suggest that reactive lipid mediators generated from this process, such as 4-hydroxynonenal (4-HNE), are biomarkers for oxidative stress and important players for mediating a number of signaling pathways. The biological effects of 4-HNE are primarily due to covalent modification of important biomolecules including proteins, DNA, and phospholipids containing amino group. In this review, we summarize recent progress on the role of 4-HNE in pathogenesis of cancer and focus on the involvement of mitochondria: generation of 4-HNE from oxidation of mitochondria-specific phospholipicl cardiolipin; covalent modification of mitochondrial proteins, lipids, and DNA; potential therapeutic strategies for targeting mitochondrial ROS generation, lipid peroxidation, and 4-HNE. (C) 2014 The Authors. Published by Elsevier B.V.
关键词	Lipid peroxidation 4-HNE Mitochondria Cancer Free radicals Cardiolipin
收录类别	SCI
语种	英语
资助项目	COST[CM1001]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000350813800022
出版者	ELSEVIER SCIENCE BV
WOS关键词	OXIDATIVE STRESS ; COMPLEX-I ; ALDEHYDE DEHYDROGENASES ; UNCOUPLING PROTEIN-2 ; HYDROXY-ALKENALS ; HUMAN-DISEASES ; FATTY-ACIDS ; CARDIOLIPIN ; MECHANISMS ; APOPTOSIS
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2236
专题	生命科学与技术学院_特聘教授组_尹慧勇组
通讯作者	Yin, Huiyong
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Univ Chinese Acad Sci, Beijing, Peoples R China 3.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhong, Huiqin,Yin, Huiyong. Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria[J]. REDOX BIOLOGY,2015,4:193-199.
APA	Zhong, Huiqin,&Yin, Huiyong.(2015).Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria.REDOX BIOLOGY,4,193-199.
MLA	Zhong, Huiqin,et al."Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria".REDOX BIOLOGY 4(2015):193-199.