Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin

doi:10.1186/s12990-015-0019-0

	Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin
	Ma, Xiao-Li 1,2; Zhang, Fang-Xiong 1,2; Dong, Fei 1,2; Bao, Lan3,4 ; Zhang, Xu1,2,4
	2015-04-22
发表期刊	MOLECULAR PAIN
ISSN	1744-8069
卷号	11
发表状态	已发表
DOI	10.1186/s12990-015-0019-0
摘要	The single application of high-concentration of capsaicin has been used as an analgesic therapy of persistent pain. However, its effectiveness and underlying mechanisms remain to be further evaluated with experimental approaches. The present study provided evidence showing that the single application of capsaicin dose-dependently alleviated nociceptive hypersensitivity, and reduced the action potential firing in small-diameter neurons of the dorsal root ganglia (DRG) in rats and mice. Pre-treatment with capsaicin reduced formalin-induced acute nocifensive behavior after a brief hyperalgesia in rats and mice. The inhibitory effects of capsaicin were calcium-dependent, and mediated by the capsaicin receptor (transient receptor potential vanilloid type-1). We further found that capsaicin exerted inhibitory effects on the persistent nociceptive hypersensitivity induced by peripheral inflammation and nerve injury. Thus, these results support the long-lasting and inhibitory effects of topical capsaicin on persistent pain, and the clinic use of capsaicin as a pain therapy.
收录类别	SCI
语种	英语
资助项目	Chinese Academy of Sciences[XDB01020300]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000353947400001
出版者	SAGE PUBLICATIONS INC
WOS关键词	DORSAL-ROOT GANGLION ; PRIMARY AFFERENT NEURONS ; EPIDERMAL NERVE-FIBERS ; GATED SODIUM CURRENTS ; NEUROPATHIC PAIN ; TOPICAL CAPSAICIN ; VANILLOID RECEPTOR ; 8-PERCENT PATCH ; SENSORY NEURONS ; TRPV1
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2223
专题	生命科学与技术学院_特聘教授组_鲍岚组生命科学与技术学院_特聘教授组_张旭组
通讯作者	Zhang, Xu
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, Inst Neurosci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci, State Key Lab Neurosci, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai 200031, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Ma, Xiao-Li,Zhang, Fang-Xiong,Dong, Fei,et al. Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin[J]. MOLECULAR PAIN,2015,11.
APA	Ma, Xiao-Li,Zhang, Fang-Xiong,Dong, Fei,Bao, Lan,&Zhang, Xu.(2015).Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin.MOLECULAR PAIN,11.
MLA	Ma, Xiao-Li,et al."Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin".MOLECULAR PAIN 11(2015).