Differential Natural Selection of Human Zinc Transporter Genes between African and Non-African Populations

doi:10.1038/srep09658

	Differential Natural Selection of Human Zinc Transporter Genes between African and Non-African Populations
	Zhang, Chao 1; Li, Jing 1; Tian, Lei 1; Lu, Dongsheng 1; Yuan, Kai 1; Yuan, Yuan 1; Xu, Shuhua1,2,3
	2015-04-30
发表期刊	SCIENTIFIC REPORTS (IF:3.8[JCR-2023],4.3[5-Year])
ISSN	2045-2322
卷号	5
发表状态	已发表
DOI	10.1038/srep09658
摘要	Zinc transporters play important roles in all eukaryotes by maintaining the rational zinc concentration in cells. However, the diversity of zinc transporter genes (ZTGs) remains poorly studied. Here, we investigated the genetic diversity of 24 human ZTGs based on the 1000 Genomes data. Some ZTGs show small population differences, such as SLC30A6 with a weighted-average F-ST (WA-F-ST = 0.015), while other ZTGs exhibit considerably large population differences, such as SLC30A9 (WA-F-ST = 0.284). Overall, ZTGs harbor many more highly population-differentiated variants compared with random genes. Intriguingly, we found that SLC30A9 was underlying natural selection in both East Asians (EAS) and Africans (AFR) but in different directions. Notably, a non-synonymous variant (rs1047626) in SLC30A9 is almost fixed with 96.4% A in EAS and 92% G in AFR, respectively. Consequently, there are two different functional haplotypes exhibiting dominant abundance in AFR and EAS, respectively. Furthermore, a strong correlation was observed between the haplotype frequencies of SLC30A9 and distributions of zinc contents in soils or crops. We speculate that the genetic differentiation of ZTGs could directly contribute to population heterogeneity in zinc transporting capabilities and local adaptations of human populations in regard to the local zinc state or diets, which have both evolutionary and medical implications.
收录类别	SCI
语种	英语
资助项目	Knowledge Innovation Program of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences[2013KIP108]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000353897500001
出版者	NATURE PUBLISHING GROUP
WOS关键词	GENOME-WIDE ASSOCIATION ; POSITIVE SELECTION ; EXPRESSION ; INDICATORS ; VARIANTS ; GENETICS ; PROTEIN ; LOCI ; DIVERSITY ; SUBFAMILY
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2220
专题	生命科学与技术学院_特聘教授组_徐书华组
通讯作者	Xu, Shuhua
作者单位	1.Chinese Acad Sci, Max Planck Independent Res Grp Populat Gen, CAS MPG Partner Inst Computat Biol PICB, Key Lab Computat Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.ShanghaiTec Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 3.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhang, Chao,Li, Jing,Tian, Lei,et al. Differential Natural Selection of Human Zinc Transporter Genes between African and Non-African Populations[J]. SCIENTIFIC REPORTS,2015,5.
APA	Zhang, Chao.,Li, Jing.,Tian, Lei.,Lu, Dongsheng.,Yuan, Kai.,...&Xu, Shuhua.(2015).Differential Natural Selection of Human Zinc Transporter Genes between African and Non-African Populations.SCIENTIFIC REPORTS,5.
MLA	Zhang, Chao,et al."Differential Natural Selection of Human Zinc Transporter Genes between African and Non-African Populations".SCIENTIFIC REPORTS 5(2015).