Signaling networks controlling ID and E protein activity in T cell differentiation and function
Hwang, Sung-Min1; Im, Sin-Hyeog2,3,4; Rudra, Dipayan5
2022-08-02
发表期刊FRONTIERS IN IMMUNOLOGY
ISSN1664-3224
卷号13
发表状态已发表
DOI10.3389/fimmu.2022.964581
摘要E and inhibitor of DNA binding (ID) proteins are involved in various cellular developmental processes and effector activities in T cells. Recent findings indicate that E and ID proteins are not only responsible for regulating thymic T cell development but also modulate the differentiation, function, and fate of peripheral T cells in multiple immune compartments. Based on the well-established E and ID protein axis (E-ID axis), it has been recognized that ID proteins interfere with the dimerization of E proteins, thus restricting their transcriptional activities. Given this close molecular relationship, the extent of expression or stability of these two protein families can dynamically affect the expression of specific target genes involved in multiple aspects of T cell biology. Therefore, it is essential to understand the endogenous proteins or extrinsic signaling pathways that can influence the dynamics of the E-ID axis in a cell-specific and context-dependent manner. Here, we provide an overview of E and ID proteins and the functional outcomes of the E-ID axis in the activation and function of multiple peripheral T cell subsets, including effector and memory T cell populations. Further, we review the mechanisms by which endogenous proteins and signaling pathways alter the E-ID axis in various T cell subsets influencing T cell function and fate at steady-state and in pathological settings. A comprehensive understanding of the functions of E and ID proteins in T cell biology can be instrumental in T cell-specific targeting of the E-ID axis to develop novel therapeutic modalities in the context of autoimmunity and cancer.
关键词E proteins ID proteins E-ID axis T cell differentiation T cell function regulatory T (Treg) cells signaling pathways
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收录类别SCI ; SCIE
语种英语
WOS研究方向Immunology
WOS类目Immunology
WOS记录号WOS:000841178300001
出版者FRONTIERS MEDIA SA
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/219672
专题生命科学与技术学院_PI研究组_Dipayan Rudra组
通讯作者Im, Sin-Hyeog; Rudra, Dipayan
作者单位1.Weill Cornell Med, Dept Obstet & Gynecol, New York, NY USA
2.Pohang Univ Sci & Technol, Dept Life Sci, Pohang, South Korea
3.Yonsei Univ, Inst Convergence Res & Educ, Seoul, South Korea
4.ImmunoBiome Inc, Bio Open Innovat Ctr, Pohang, South Korea
5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位生命科学与技术学院
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Hwang, Sung-Min,Im, Sin-Hyeog,Rudra, Dipayan. Signaling networks controlling ID and E protein activity in T cell differentiation and function[J]. FRONTIERS IN IMMUNOLOGY,2022,13.
APA Hwang, Sung-Min,Im, Sin-Hyeog,&Rudra, Dipayan.(2022).Signaling networks controlling ID and E protein activity in T cell differentiation and function.FRONTIERS IN IMMUNOLOGY,13.
MLA Hwang, Sung-Min,et al."Signaling networks controlling ID and E protein activity in T cell differentiation and function".FRONTIERS IN IMMUNOLOGY 13(2022).
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