ShanghaiTech University Knowledge Management System
Signaling networks controlling ID and E protein activity in T cell differentiation and function | |
Hwang, Sung-Min1; Im, Sin-Hyeog2,3,4; Rudra, Dipayan5 | |
2022-08-02 | |
发表期刊 | FRONTIERS IN IMMUNOLOGY |
ISSN | 1664-3224 |
卷号 | 13 |
发表状态 | 已发表 |
DOI | 10.3389/fimmu.2022.964581 |
摘要 | E and inhibitor of DNA binding (ID) proteins are involved in various cellular developmental processes and effector activities in T cells. Recent findings indicate that E and ID proteins are not only responsible for regulating thymic T cell development but also modulate the differentiation, function, and fate of peripheral T cells in multiple immune compartments. Based on the well-established E and ID protein axis (E-ID axis), it has been recognized that ID proteins interfere with the dimerization of E proteins, thus restricting their transcriptional activities. Given this close molecular relationship, the extent of expression or stability of these two protein families can dynamically affect the expression of specific target genes involved in multiple aspects of T cell biology. Therefore, it is essential to understand the endogenous proteins or extrinsic signaling pathways that can influence the dynamics of the E-ID axis in a cell-specific and context-dependent manner. Here, we provide an overview of E and ID proteins and the functional outcomes of the E-ID axis in the activation and function of multiple peripheral T cell subsets, including effector and memory T cell populations. Further, we review the mechanisms by which endogenous proteins and signaling pathways alter the E-ID axis in various T cell subsets influencing T cell function and fate at steady-state and in pathological settings. A comprehensive understanding of the functions of E and ID proteins in T cell biology can be instrumental in T cell-specific targeting of the E-ID axis to develop novel therapeutic modalities in the context of autoimmunity and cancer. |
关键词 | E proteins ID proteins E-ID axis T cell differentiation T cell function regulatory T (Treg) cells signaling pathways |
URL | 查看原文 |
收录类别 | SCI ; SCIE |
语种 | 英语 |
WOS研究方向 | Immunology |
WOS类目 | Immunology |
WOS记录号 | WOS:000841178300001 |
出版者 | FRONTIERS MEDIA SA |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/219672 |
专题 | 生命科学与技术学院_PI研究组_Dipayan Rudra组 |
通讯作者 | Im, Sin-Hyeog; Rudra, Dipayan |
作者单位 | 1.Weill Cornell Med, Dept Obstet & Gynecol, New York, NY USA 2.Pohang Univ Sci & Technol, Dept Life Sci, Pohang, South Korea 3.Yonsei Univ, Inst Convergence Res & Educ, Seoul, South Korea 4.ImmunoBiome Inc, Bio Open Innovat Ctr, Pohang, South Korea 5.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Hwang, Sung-Min,Im, Sin-Hyeog,Rudra, Dipayan. Signaling networks controlling ID and E protein activity in T cell differentiation and function[J]. FRONTIERS IN IMMUNOLOGY,2022,13. |
APA | Hwang, Sung-Min,Im, Sin-Hyeog,&Rudra, Dipayan.(2022).Signaling networks controlling ID and E protein activity in T cell differentiation and function.FRONTIERS IN IMMUNOLOGY,13. |
MLA | Hwang, Sung-Min,et al."Signaling networks controlling ID and E protein activity in T cell differentiation and function".FRONTIERS IN IMMUNOLOGY 13(2022). |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 |
修改评论
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。