Clickable Selenylation - a Paradigm for Seleno-Medicinal Chemistry

doi:10.1002/cmdc.202200324

	Clickable Selenylation - a Paradigm for Seleno-Medicinal Chemistry
	Hou, Wei 1,2; Dong, Hewei 1,2; Yao, Ying3 ; Pan, Kangyin3 ; Yang, Guang3 ; Ma, Peixiang3,4 ; Xu, Hongtao3
	2022-09-05
发表期刊	CHEMMEDCHEM (IF:3.6[JCR-2023],3.5[5-Year])
ISSN	1860-7179
EISSN	1860-7187
发表状态	已发表
DOI	10.1002/cmdc.202200324
摘要	Selenium (Se) is an emerging versatile player in medicinal chemistry. The incorporation of Se into small molecules and natural products could have multiple benefits. However, the lack of efficient methods for the synthesis of Se-containing chemical library has greatly hindered the development of seleno-medicinal chemistry. With the aim to address this issue, we proposed the development of "clickable selenylation" reactions, which can be used in the synthesis of Se-containing in situ library and DNA-encoded library (SeDEL), thereby quickly producing ultra-large collections of Se-containing compounds and boosting the development of seleno-medicinal chemistry. This research paradigm can be concluded as "clickable selenylation chemistry development -> in situ library construction/SeDEL synthesis -> phenotype- or target-based screening -> seleno-hit compound".
关键词	Selenium Parallel Synthesis DNA-encoded Library Drug Discovery Drug screening
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	Natural Science Foundation of Shanghai, China[21ZR1442900] ; National Natural Science Foundation of China["21977070","21907085","22177073","U19A2011"] ; Natural Science Foundation of Zhejiang Province, China[LY22H300001] ; Ministry of Science and Technology of China[2021YFA1100800] ; Key Research Project of Zhejiang Lab, China[2021PE0AC06]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000839455400001
出版者	WILEY-V C H VERLAG GMBH
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/219666
专题	生命科学与技术学院_硕士生免疫化学研究所_特聘教授组_功能筛选实验室免疫化学研究所_特聘教授组_抗体设计学实验室生命科学与技术学院_博士生
通讯作者	Ma, Peixiang; Xu, Hongtao
作者单位	1.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China 2.Zhejiang Univ Technol, Inst Drug Dev & Chem Biol, Hangzhou 310014, Peoples R China 3.ShanghaiTech Univ, Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China 4.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthoped Implants, Shanghai 201210, Peoples R China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Hou, Wei,Dong, Hewei,Yao, Ying,et al. Clickable Selenylation - a Paradigm for Seleno-Medicinal Chemistry[J]. CHEMMEDCHEM,2022.
APA	Hou, Wei.,Dong, Hewei.,Yao, Ying.,Pan, Kangyin.,Yang, Guang.,...&Xu, Hongtao.(2022).Clickable Selenylation - a Paradigm for Seleno-Medicinal Chemistry.CHEMMEDCHEM.
MLA	Hou, Wei,et al."Clickable Selenylation - a Paradigm for Seleno-Medicinal Chemistry".CHEMMEDCHEM (2022).