Fine-scale population structure of Malays in Peninsular Malaysia and Singapore and implications for association studies

doi:10.1186/s40246-015-0039-x

	Fine-scale population structure of Malays in Peninsular Malaysia and Singapore and implications for association studies
	Hoh, Boon-Peng 1,2,3; Deng, Lian 1; Julia-Ashazila, Mat Jusoh 2; Zuraihan, Zakaria 2; Nur-Hasnah, Ma'amor 2; Nur-Shafawati, Ab Rajab 4; Hatin, Wan Isa 4; Endom, Ismail 5; Zilfalil, Bin Alwi 6; Khalid, Yusoff 2,7; Xu, Shuhua1,8,9
	2015-07-22
发表期刊	HUMAN GENOMICS
ISSN	1473-9542
卷号	9
发表状态	已发表
DOI	10.1186/s40246-015-0039-x
摘要	Fine scale population structure of Malays - the major population in Malaysia, has not been well studied. This may have important implications for both evolutionary and medical studies. Here, we investigated the population sub-structure of Malay involving 431 samples collected from all states from peninsular Malaysia and Singapore. We identified two major clusters of individuals corresponding to the north and south peninsular Malaysia. On an even finer scale, the genetic coordinates of the geographical Malay populations are in correlation with the latitudes (R-2 = 0.3925; P = 0.029). This finding is further supported by the pairwise F-ST of Malay sub-populations, of which the north and south regions showed the highest differentiation (F-ST ([North-south]) = 0.0011). The collective findings therefore suggest that population sub-structure of Malays are more heterogenous than previously expected even within a small geographical region, possibly due to factors like different genetic origins, geographical isolation, could result in spurious association as demonstrated in our analysis. We suggest that cautions should be taken during the stage of study design or interpreting the association signals in disease mapping studies which are expected to be conducted in Malay population in the near future.
关键词	Malay Population sub-structure F-ST Latitude-PC correlation GWAS simulation
收录类别	SCI
语种	英语
资助项目	USM short term grant[304 / PPSP / 61311034]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000358191300001
出版者	BIOMED CENTRAL LTD
WOS关键词	CYP1B1 GENE-MUTATIONS ; HAN CHINESE ; ANCESTRY ; GLAUCOMA
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2173
专题	生命科学与技术学院_特聘教授组_徐书华组
通讯作者	Hoh, Boon-Peng
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Max Planck Independent Res Grp Populat Genom, CAS MPG Partner Inst Computat Biol PICB,Key Lab C, Shanghai 200031, Peoples R China 2.Univ Teknol MARA, Fac Med, Inst Med Mol Biotechnol, Selangor, Malaysia 3.UCSI Univ, Kuala Lumpur, Malaysia 4.Univ Sains Malaysia, Sch Med Sci, Ctr Human Genome, Kelantan 16150, Malaysia 5.Univ Kebangsaan Malaysia, Fac Sci & Technol, Sch Biosci & Biotechnol, Bangi 43600, Malaysia 6.Univ Sains Malaysia, Sch Med Sci, Dept Pediat, Kelantan 16150, Malaysia 7.UCSI Univ, Kuala Lumpur 56000, Wilayah Perseku, Malaysia 8.ShanghaiTec Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 9.Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China
推荐引用方式 GB/T 7714	Hoh, Boon-Peng,Deng, Lian,Julia-Ashazila, Mat Jusoh,et al. Fine-scale population structure of Malays in Peninsular Malaysia and Singapore and implications for association studies[J]. HUMAN GENOMICS,2015,9.
APA	Hoh, Boon-Peng.,Deng, Lian.,Julia-Ashazila, Mat Jusoh.,Zuraihan, Zakaria.,Nur-Hasnah, Ma'amor.,...&Xu, Shuhua.(2015).Fine-scale population structure of Malays in Peninsular Malaysia and Singapore and implications for association studies.HUMAN GENOMICS,9.
MLA	Hoh, Boon-Peng,et al."Fine-scale population structure of Malays in Peninsular Malaysia and Singapore and implications for association studies".HUMAN GENOMICS 9(2015).