Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic beta-cell insulin secretion

doi:10.1016/j.bbrc.2015.07.016

	Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic beta-cell insulin secretion
	Liu, Xiaojing 1,2; Han, Shuai 1; Yang, Ying 1; Kang, Jiuhong 2; Wu, Jiarui1,3,4
	2015-08-28
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (IF:2.5[JCR-2023],2.7[5-Year])
ISSN	0006-291X
卷号	464 期号:3 页码:730-736
发表状态	已发表
DOI	10.1016/j.bbrc.2015.07.016
摘要	Glucose can acutely reduce mitochondrial glutathione redox state in rat islets. However, whether glucose-stimulated mitochondrial glutathione redox state relates to glucose-stimulated insulin secretion (GSIS) remains unknown. We used genetically encoded redox-sensitive GFPs to target the mitochondria to monitor glutathione redox changes during GSIS in rat pancreatic beta-cells. The results showed that mitochondrial glutathione was more reduced during GSIS, whereas inhibition of this glutathione reduction impaired insulin secretion. In isolated rat pancreatic islets glutathione reduction in mitochondria and the first phase of GSIS were concurrence at the early stage of glucose-stimulation. Our results suggest that the glucose-induced glutathione reduction in mitochondria is primarily required for the first phase of GSIS. (C) 2015 The Authors. Published by Elsevier Inc.
关键词	Glutathione Redox Insulin secretion Mitochondria Pancreatic beta-cell
收录类别	SCI
语种	英语
资助项目	Science and Technology Commission of Shanghai Municipality[13DZ1940100]
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000359881900009
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词	PROTEIN GLUTATHIONYLATION ; AMPLIFYING PATHWAYS ; DEHYDROGENASE ; INACTIVATION ; SULFOXIMINE ; SENSITIVITY ; INHIBITION ; METABOLISM ; MECHANISMS ; SIGNAL
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2152
专题	生命科学与技术学院
通讯作者	Wu, Jiarui
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China 2.Tongji Univ, Sch Life Sci & Technol, Shanghai Key Lab Signaling & Dis Res, Shanghai Matern & Infant Hlth Hosp 1,Clin & Trans, Shanghai 200092, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Liu, Xiaojing,Han, Shuai,Yang, Ying,et al. Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic beta-cell insulin secretion[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,464(3):730-736.
APA	Liu, Xiaojing,Han, Shuai,Yang, Ying,Kang, Jiuhong,&Wu, Jiarui.(2015).Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic beta-cell insulin secretion.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,464(3),730-736.
MLA	Liu, Xiaojing,et al."Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic beta-cell insulin secretion".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 464.3(2015):730-736.