Specific gut microbiota alterations in essential tremor and its difference from Parkinson’s disease

doi:10.1038/s41531-022-00359-y

	Specific gut microbiota alterations in essential tremor and its difference from Parkinson’s disease
	Zhang, Pingchen 1; Huang, Pei 1; Du, Juanjuan 1; He, Yixi 1; Liu, Jin 1; He, Guiying 1; Cui, Shishuang 1; Zhang, Weishan 1; Li, Gen 1; Chen, Shengdi1,2
	2022-08-05
发表期刊	NPJ PARKINSON'S DISEASE
EISSN	2373-8057
卷号	8 期号:1
发表状态	已发表
DOI	10.1038/s41531-022-00359-y
摘要	Essential tremor (ET) is the most common movement disorder and share overlapping symptoms with Parkinson’s disease (PD), making differential diagnosis challenging. Gut dysbiosis is regarded crucial in the pathogenesis of PD. Since ET patients also has comorbidity in gastrointestinal disorders, the relationship between gut microbiota and ET really worth investigating and may help distinguishing ET from PD. Fecal samples from 54 ET, 67 de novo PD and 54 normal controls (NC) were collected for 16S ribosomal RNA gene sequencing and quantitative real-time PCR. ET showed lower species richness (Chao1 index) than NC and PD. ET was with Bacteroides-dominant enterotype, while PD was with Ruminococcus-dominant enterotype. Compared with NC, 7 genera were significantly reduced in ET, 4 of which (Ruminococcus, Romboutsia, Mucispirillum, and Aeromonas) were identified to be distinctive with an area under the curve (AUC) of 0.705. Compared to PD, 26 genera were found significantly different from ET, 4 of which (Bacteroides, Fusobacterium, Phascolarctobacterium, and Lachnospira) were found distinguishable with an AUC of 0.756. Clinical association results indicated that Proteus was associated with disease severity (TETRAS) of ET, while Klebsiella was linked to depression and anxiety in ET. Functional predictions revealed that 4 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were altered in ET. This study reveals gut dysbiosis in ET and it provides new insight into the pathogenesis of ET and helps distinguishing ET from PD.
URL	查看原文
收录类别	SCIE
语种	英语
Scopus 记录号	2-s2.0-85135447713
来源库	Scopus
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/214815
专题	免疫化学研究所_特聘教授组_陈生弟组
通讯作者	Chen, Shengdi
作者单位	1.Department of Neurology and Institute of Neurology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200025,China 2.Lab for Translational Research of Neurodegenerative Diseases,Shanghai Institute for Advanced Immunochemical Studies (SIAIS),Shanghai Tech University,Shanghai,201210,China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Zhang, Pingchen,Huang, Pei,Du, Juanjuan,et al. Specific gut microbiota alterations in essential tremor and its difference from Parkinson’s disease[J]. NPJ PARKINSON'S DISEASE,2022,8(1).
APA	Zhang, Pingchen.,Huang, Pei.,Du, Juanjuan.,He, Yixi.,Liu, Jin.,...&Chen, Shengdi.(2022).Specific gut microbiota alterations in essential tremor and its difference from Parkinson’s disease.NPJ PARKINSON'S DISEASE,8(1).
MLA	Zhang, Pingchen,et al."Specific gut microbiota alterations in essential tremor and its difference from Parkinson’s disease".NPJ PARKINSON'S DISEASE 8.1(2022).