Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human

doi:10.1038/s41467-022-31403-3

	Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human
	Yao, Xuelong 1,2,3; Lu, Zongyang2,4,5 ; Feng, Zhanying 2,6; Gao, Lei 1; Zhou, Xin 7; Li, Min 2,7; Zhong, Suijuan 8,9; Wu, Qian 8,9; Liu, Zhenbo 1; Zhang, Haofeng 10; Liu, Zeyuan 2,7; Yi, Lizhi 1,2; Zhou, Tao4,11 ; Zhao, Xudong 12; Zhang, Jun 10; Wang, Yong 2,6,13; Huang, Xingxu4,14 ; Wang, Xiaoqun 2,7,15,16; Liu, Jiang 1,2,13
	2022-12-01
发表期刊	NATURE COMMUNICATIONS
EISSN	2041-1723
卷号	13 期号:1
发表状态	已发表
DOI	10.1038/s41467-022-31403-3
摘要	Epigenetic information regulates gene expression and development. However, our understanding of the evolution of epigenetic regulation on brain development in primates is limited. Here, we compared chromatin accessibility landscapes and transcriptomes during fetal prefrontal cortex (PFC) development between rhesus macaques and humans. A total of 304,761 divergent DNase I-hypersensitive sites (DHSs) are identified between rhesus macaques and humans, although many of these sites share conserved DNA sequences. Interestingly, most of the cis-elements linked to orthologous genes with dynamic expression are divergent DHSs. Orthologous genes expressed at earlier stages tend to have conserved cis-elements, whereas orthologous genes specifically expressed at later stages seldom have conserved cis-elements. These genes are enriched in synapse organization, learning and memory. Notably, DHSs in the PFC at early stages are linked to human educational attainment and cognitive performance. Collectively, the comparison of the chromatin epigenetic landscape between rhesus macaques and humans suggests a potential role for regulatory elements in the evolution of differences in cognitive ability between non-human primates and humans.
URL	查看原文
收录类别	SCIE
语种	英语
Scopus 记录号	2-s2.0-85133578524
来源库	Scopus
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/214809
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_黄行许组
作者单位	1.CAS Key Laboratory of Genome Sciences and Information,Collaborative Innovation Center of Genetics and Development,Beijing Institute of Genomics,Chinese Academy of Sciences and China National Center for Bioinformation,Beijing,100101,China 2.University of Chinese Academy of Sciences,Beijing,100049,China 3.Guangzhou Nvwa Life Technology Co.,Ltd,Guangzhou,510535,China 4.School of Life Science and Technology,Shanghai Tech University,Shanghai,100 Haike Rd., Pudong New Area,201210,China 5.Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai,320 Yueyang Road,200031,China 6.CEMS,NCMIS,MDIS,Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing,100190,China 7.State Key Laboratory of Brain and Cognitive Science,CAS Center for Excellence in Brain Science and Intelligence Technology,Institute of Brain-Intelligence Technology (Shanghai),Institute of Biophysics,Chinese Academy of Sciences,Beijing,100101,China 8.State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University,Beijing,100875,China 9.IDG/McGovern Institute for Brain Research,Beijing Normal University,Beijing,100875,China 10.Obstetrics and Gynecology Medical Center of Severe Cardiovascular of Beijing Anzhen Hospital,Capital Medical University,Beijing,100029,China 11.Shenzhen Key Lab of Drug Addiction; The Brain Cognition and Brain Disease Institute (BCBDI),Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen,518055,China 12.Kunming Primate Research Center,Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,650223,China 13.Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming,650223,China 14.Zhejiang Provincial Key Laboratory of Pancreatic Disease,The First Affiliated Hospital,and Institute of Translational Medicine,Zhejiang University School of Medicine,Hangzhou,Zhejiang,310058,China 15.Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing,100101,China 16.Beijing Institute for Brain Disorders,Beijing,100069,China
推荐引用方式 GB/T 7714	Yao, Xuelong,Lu, Zongyang,Feng, Zhanying,et al. Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human[J]. NATURE COMMUNICATIONS,2022,13(1).
APA	Yao, Xuelong.,Lu, Zongyang.,Feng, Zhanying.,Gao, Lei.,Zhou, Xin.,...&Liu, Jiang.(2022).Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human.NATURE COMMUNICATIONS,13(1).
MLA	Yao, Xuelong,et al."Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human".NATURE COMMUNICATIONS 13.1(2022).