The Patent Foramen Ovale and Migraine: Associated Mechanisms and Perspectives from MRI Evidence

doi:10.3390/brainsci12070941

	The Patent Foramen Ovale and Migraine: Associated Mechanisms and Perspectives from MRI Evidence
	Cao, Wenfei 1; Shen, Yinbo 1; Zhong, Jiaqi 1; Chen, Zhenhong 1; Wang, Nizhuan2 ; Yang, Jiajun 1
	2022-07
发表期刊	BRAIN SCIENCES (IF:2.7[JCR-2023],3.0[5-Year])
EISSN	2076-3425
卷号	12 期号:7
发表状态	已发表
DOI	10.3390/brainsci12070941
摘要	Migraine is a common neurological disease with a still-unclear etiology and pathogenesis. Patent foramen ovale (PFO) is a kind of congenital heart disease that leads to a right-to-left shunt (RLS). Although previous studies have shown that PFO has an effect on migraine, a clear conclusion about the link between PFO and migraine is lacking. We first summarized the PFO potential mechanisms associated with migraine, including microembolus-triggered cortical spreading depression (CSD), the vasoactive substance hypothesis, impaired cerebral autoregulation (CA), and a common genetic basis. Further, we analyzed the changes in brain structure and function in migraine patients and migraine patients with PFO. We found that in migraine patients with PFO, the presence of PFO may affect the structure of the cerebral cortex and the integrity of white matter, which is mainly locked in subcortical, deep white matter, and posterior circulation, and may lead to changes in brain function, such as cerebellum and colliculus, which are involved in the processing and transmission of pain. In summary, this paper provides neuroimaging evidence and new insights into the correlation between PFO and migraine, which will help to clarify the etiology and pathogenesis of migraine, and aid in the diagnosis and treatment of migraine in the future.
关键词	patent foramen ovale right-to-left shunt migraine mechanism gray matter white matter hyperintensities magnetic resonance imaging functional magnetic resonance imaging
URL	查看原文
收录类别	SCI ; SCIE
语种	英语
资助项目	Shanghai Science and Technology CommissionWestern Medicine Guidance Project[19411971400] ; Pudong New Area Science and Technology Development Fund[PKJ2014-Y08] ; Project of "Six Talent Peaks" of Jiangsu Province[SWYY-017]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000832039900001
出版者	MDPI
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/214783
专题	生物医学工程学院_PI研究组_沈定刚组
通讯作者	Wang, Nizhuan; Yang, Jiajun
作者单位	1.Shanghai Jiao Tong Univ, Dept Neurol, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China 2.ShanghaiTech Univ, Sch Biomed Engn, Shanghai 201210, Peoples R China
通讯作者单位	生物医学工程学院
推荐引用方式 GB/T 7714	Cao, Wenfei,Shen, Yinbo,Zhong, Jiaqi,et al. The Patent Foramen Ovale and Migraine: Associated Mechanisms and Perspectives from MRI Evidence[J]. BRAIN SCIENCES,2022,12(7).
APA	Cao, Wenfei,Shen, Yinbo,Zhong, Jiaqi,Chen, Zhenhong,Wang, Nizhuan,&Yang, Jiajun.(2022).The Patent Foramen Ovale and Migraine: Associated Mechanisms and Perspectives from MRI Evidence.BRAIN SCIENCES,12(7).
MLA	Cao, Wenfei,et al."The Patent Foramen Ovale and Migraine: Associated Mechanisms and Perspectives from MRI Evidence".BRAIN SCIENCES 12.7(2022).